Evidence map›Paper›PMID 24991908›Full record

Trial reportAIDS (London, England)2014

A randomized clinical trial of an intervention to promote resilience in young children of HIV-positive mothers in South Africa.

Irma Eloff, Michelle Finestone, Jennifer D Makin, Alex Boeving-Allen, Maretha Visser, Liesel Ebersöhn, Ronél Ferreira, Kathleen J Sikkema, Margaret J Briggs-Gowan, Brian W C Forsyth

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AIDS (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  3. A Systematic Review and Meta-Analysis of Interventions for Orphans and Vulnerable Children Affected by HIV/AIDS Worldwide.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Irma EloffaFaculty of Education bDepartment of Obstetrics and Gynaecology, University of Pretoria, Pretoria, South Africa cDepartment of Pediatrics, Wake Forest University, Winston-Salem, North Carolina, USA dDepartment of Psychology, University of Pretoria, Pretoria, South Africa eDepartment of Psychology and Neuroscience, and Global Health, Duke University, Durham, North Carolina fDepartment of Psychiatry, University of Connecticut Health Center, Farmington gDepartment of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA.
Michelle Finestone
Jennifer D Makin
Alex Boeving-Allen
Maretha Visser
Liesel Ebersöhn
Ronél Ferreira
Kathleen J Sikkema
Margaret J Briggs-Gowan
Brian W C Forsyth

Funding

Using Coincidence Analysis to Investigate Factors Affecting PrEP Initiation and Continuation in Southern ending the Epidemic CountiesP30MH062294 · NIMH · YALE UNIVERSITY · PI John Edward Pachankis · 2001 to 2026
$48.5M
Promoting Resilience in Young Children of HIV-Infected Mothers in South AfricaR01MH076442 · NIMH · YALE UNIVERSITY · PI FORSYTH, BRIAN WILLIAM · 2005 to 2009
$2.7M
NIMH NIH HHS 5R01MH076442NIMH NIH HHS P30 MH062294NIMH NIH HHS R01 MH076442
6 · The paper itself

Abstract

objectiveThe objective of this study is to assess the efficacy of an intervention designed to promote resilience in young children living with their HIV-positive mothers. DESIGN/

methodsHIV-positive women attending clinics in Tshwane, South Africa, and their children, aged 6-10 years, were randomized to the intervention (I) or standard care (S). The intervention consisted of 24 weekly group sessions led by community care workers. Mothers and children were in separate groups for 14 sessions, followed by 10 interactive sessions. The primary focus was on parent-child communication and parenting. Assessments were completed by mothers and children at baseline and 6, 12 and 18 months. Repeated mixed linear analyses were used to assess change over time.

resultsOf 390 mother-child pairs, 84.6% (I: 161 and S: 169) completed at least two interviews and were included in the analyses. Children's mean age was 8.4 years and 42% of mothers had been ill in the prior 3 months. Attendance in groups was variable: only 45.7% attended more than 16 sessions. Intervention mothers reported significant improvements in children's externalizing behaviours (ß = -2.8, P = 0.002), communication (ß = 4.3, P = 0.025) and daily living skills (ß = 5.9, P = 0.024), although improvement in internalizing behaviours and socialization was not significant (P = 0.061 and 0.052, respectively). Intervention children reported a temporary increase in anxiety but did not report differences in depression or emotional intelligence.

conclusionThis is the first study demonstrating benefits of an intervention designed to promote resilience among young children of HIV-positive mothers. The intervention was specifically designed for an African context and has the potential to benefit large numbers of children, if it can be widely implemented.

Indexed as

Behavior TherapyMother-Child RelationsMothersResilience, PsychologicalAdultChildFemaleHIV InfectionsHumansMalePregnancySouth AfricaTreatment Outcome

Identifiers

PMID24991908
PMCPMC4160802

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.