ArticlePloS one2014
Basolateral junction proteins regulate competition for the follicle stem cell niche in the Drosophila ovary.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Starve-Feed Cycles Direct Quiescence to Proliferation Transitions inbioRxiv : the preprint server for biology · 2026Article
- Licensing and niche competition in spermatogenesis: mathematical models suggest complementary regulation of tissue maintenance.Development (Cambridge, England) · 2025Article
- Mechanisms of Germline Stem Cell Competition across Species.Life (Basel, Switzerland) · 2024Review
- Sequential events during the quiescence to proliferation transition establish patterns of follicle cell differentiation in the Drosophila ovary.Biology open · 2023Article
- Human papillomavirus type 16 E6 induces cell competition.PLoS pathogens · 2022Article
- Distinct roles of Bendless in regulating FSC niche competition and daughter cell differentiation.Development (Cambridge, England) · 2021Article
- Transcriptomic analysis of feminizing somatic stem cells in the Drosophila testis reveals putative downstream effectors of the transcription factor Chinmo.G3 (Bethesda, Md.) · 2021Article
- Tracing the Dynamics of Stem Cell Fate.Cold Spring Harbor perspectives in biology · 2020Review
- Signal transduction in the early Drosophila follicle stem cell lineage.Current opinion in insect science · 2020Review
- The follicle epithelium in theeLife · 2019Article
- Wingless promotes EGFR signaling in follicle stem cells to maintain self-renewal.Development (Cambridge, England) · 2018Article
- Autophagy Promotes Tumor-like Stem Cell Niche Occupancy.Current biology : CB · 2018Article
- Division-independent differentiation mandates proliferative competition among stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Loss of heterogeneity, quiescence, and differentiation in muscle stem cells.Stem cell investigation · 2018Review
- Neutral Competition forGenetics · 2017Article
- The Hippo pathway acts downstream of the Hedgehog signaling to regulate follicle stem cell maintenance in the Drosophila ovary.Scientific reports · 2017Article
- Alternative direct stem cell derivatives defined by stem cell location and graded Wnt signalling.Nature cell biology · 2017Article
- Decreased expression of lethal giant larvae causes ovarian follicle cell outgrowth in the Drosophila Scutoid mutant.PloS one · 2017Article
- Phosphorylated Groucho delays differentiation in the follicle stem cell lineage by providing a molecular memory of EGFR signaling in the niche.Development (Cambridge, England) · 2016Article
- Three mechanisms control E-cadherin localization to the zonula adherens.Nature communications · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Epithelial stem cells are routinely lost or damaged during adult life and must therefore be replaced to maintain homeostasis. Recent studies indicate that stem cell replacement occurs through neutral competition in many types of epithelial tissues, but little is known about the factors that determine competitive outcome. The epithelial follicle stem cells (FSCs) in the Drosophila ovary are regularly lost and replaced during normal homeostasis, and we show that FSC replacement conforms to a model of neutral competition. In addition, we found that FSCs mutant for the basolateral junction genes, lethal giant larvae (lgl) or discs large (dlg), undergo a biased competition for niche occupancy characterized by increased invasion of neighboring FSCs and reduced loss. Interestingly, FSCs mutant for a third basolateral junction gene, scribble (scrib), do not exhibit biased competition, suggesting that Lgl and Dlg regulate niche competition through a Scrib-independent process. Lastly, we found that FSCs have a unique cell polarity characterized by broadly distributed adherens junctions and the lack of a mature apical domain. Collectively, these observations indicate that Lgl and Dlg promote the differentiation of FSC progeny to a state in which they are less prone to invade the neighboring niche. In addition, we demonstrate that the neutral drift model can be adapted to quantify non-neutral behavior of mutant clones.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.