Evidence map›Paper›PMID 24991459›Full record

ArticleAllergy, asthma & immunology research2014

Maternal Genetic Variants of IL4/IL13 Pathway Genes on IgE With "Western or Eastern Environments/Lifestyles".

Guicheng Zhang, Siew-Kim Khoo, Mika J Mäkelä, Pierre Candelaria, Catherine M Hayden, Leena von Hertzen, Tiina Laatikainen, Erkki Vartiainen, Jack Goldblatt, Tari Haahtela and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Allergy, asthma & immunology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Guicheng ZhangSchool of Paediatrics and Child Health, University of Western Australia, Australia. ; School of Public Health, Curtin University, Perth, Australia.
Siew-Kim KhooSchool of Paediatrics and Child Health, University of Western Australia, Australia.
Mika J MäkeläSkin and Allergy Hospital, Helsinki University Central Hospital, Helsinki, Finland.
Pierre CandelariaSchool of Paediatrics and Child Health, University of Western Australia, Australia.
Catherine M HaydenSchool of Paediatrics and Child Health, University of Western Australia, Australia.
Leena von HertzenSkin and Allergy Hospital, Helsinki University Central Hospital, Helsinki, Finland.
Tiina LaatikainenNational Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland.
Erkki VartiainenNational Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland.
Jack GoldblattSchool of Paediatrics and Child Health, University of Western Australia, Australia. ; Genetic Services of WA, King Edward Memorial Hospital, Perth, Australia.
Tari HaahtelaSkin and Allergy Hospital, Helsinki University Central Hospital, Helsinki, Finland.
Peter N LeSouëfSchool of Paediatrics and Child Health, University of Western Australia, Australia.
University of Western Australia · AUHelsinki University Hospital · FIFinnish Institute for Health and Welfare · FICurtin University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe investigated maternal genetic effects of four IL-4/IL-13 pathway genes as well as their interactions with the "Western or Eastern lifestyles/environments" on IgE in Karelian children.

methodsThis study included 609 children and their mothers. Total IgE levels in children and mothers were measured and 10 single nucleotide polymorphisms (SNPs) in IL-4, IL-4Ra, IL-13, and STAT6 were genotyped in mothers and their children.

resultsThe maternal G allele of IL-13 130 (rs20541) was significantly (P=0.001) associated with decreased IgE in children in the Karelian population (Pooling Finnish and Russian children), as well as in Finnish (P=0.030) and Russian children (P=0.018). The IgE levels were significantly (P=0.001) higher in Russian children whose mothers were homozygous for the G allele of the IL-4Ra 50 (rs1805010) SNP than that in Russian children of mothers who were AG heterozygotes or AA homozygotes. After accounting for children's genotypes, we observed interactive effects on children's IgE for maternal IL-13 130 genotypes (P=0.014) and maternal IL-4Ra 50 genotypes (P=0.0003) with "Western or Eastern" lifestyles/environments. With the adjustment for multiple comparisons using a false discovery rate (FDR) of 0.05, the interactive effect of the maternal IL-4Ra50 SNP was significant.

conclusionMaternal genetic variants in IL-4/IL-13 pathway genes, such as IL-13 130 and IL-4Ra50, influenced IgE levels in school children that were independent of the children's genetic effects. These effects differ in "Western or Eastern" environments.

Indexed as

AllergyIgEIL-13IL-4maternal genetic effects

Identifiers

PMID24991459
PMCPMC4077962
OpenAlexW1907964475

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.