ArticleAllergy, asthma & immunology research2014
The utility of serum tryptase in the diagnosis of food-induced anaphylaxis.
Article in Allergy, asthma & immunology research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Kounis Syndrome in the Modern Era: A Comprehensive Review of Allergic Acute Coronary Syndromes.Journal of clinical medicine · 2026Review
- Hereditary Alpha-Tryptasemia (HαT) as a Risk Modifier for Severe Anaphylaxis.Immunology and allergy clinics of North America · 2026Review
- Pediatric anaphylaxis in the emergency department: Performances of dynamic tryptase measurement.The journal of allergy and clinical immunology. Global · 2025Article
- Hereditary alpha tryptasemia and food allergy.Frontiers in allergy · 2025Review
- Alpha-Tryptase as a Risk-Modifying Factor for Mast Cell-Mediated Reactions.Current allergy and asthma reports · 2024Review
- Severe food allergy reactions are associated with α-tryptase.The Journal of allergy and clinical immunology · 2023Article
- Article
- Incorporating Tryptase Genotyping Into the Workup and Diagnosis of Mast Cell Diseases and Reactions.The journal of allergy and clinical immunology. In practice · 2022Review
- Defining baseline variability of serum tryptase levels improves accuracy in identifying anaphylaxis.The Journal of allergy and clinical immunology · 2022Article
- New Biomarkers in Anaphylaxis (Beyond Tryptase).Current treatment options in allergy · 2022Review
- Detection of Salivary Tryptase Levels in Children following Oral Food Challenges.International archives of allergy and immunology · 2022Article
- A Clinical Practice Guideline for the Emergency Management of Anaphylaxis (2020).Frontiers in pharmacology · 2022Article
- Inherited and acquired determinants of serum tryptase levels in humans.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2021Review
- Hereditary Alpha-Tryptasemia: a Commonly Inherited Modifier of Anaphylaxis.Current allergy and asthma reports · 2021Review
- Using Baseline and Peak Serum Tryptase Levels to Diagnose Anaphylaxis: a Review.Clinical reviews in allergy & immunology · 2020Review
- Mast cell activation in the context of elevated basal serum tryptase: genetics and presentations.Current allergy and asthma reports · 2019Review
- Why the 20% + 2 Tryptase Formula Is a Diagnostic Gold Standard for Severe Systemic Mast Cell Activation and Mast Cell Activation Syndrome.International archives of allergy and immunology · 2019Review
- Multifactorial Modulation of Food-Induced Anaphylaxis.Frontiers in immunology · 2017Review
- Managing nut-induced anaphylaxis: challenges and solutions.Journal of asthma and allergy · 2015Review
- 2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines.The World Allergy Organization journal · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study investigates the utility of serum tryptase for the confirmation of shrimp-induced anaphylaxis.
methodsPatients with a history of shrimp allergy and positive skin prick tests (SPT) to commercial shrimp extract were recruited for shrimp challenges. Serum total tryptase was obtained at baseline and 60 min (peak) after the onset of symptoms.
resultsThirty-nine patients were challenged. There were 12 patients with anaphylaxis, 20 with mild reactions and 7 without symptoms (control group). Characteristic features and baseline tryptase were not different among the 3 groups. The peak tryptase levels were higher than the baseline in anaphylaxis and mild reaction groups (P<0.05). The delta-tryptase (peak minus baseline) and the tryptase ratio (peak divided by baseline) in the anaphylaxis group were higher than the mild reaction and control groups (P<0.01). The optimum cut-off for peak tryptase to confirm anaphylaxis was 2.99 µg/L with 50% sensitivity, 85% specificity, 3.33 positive likelihood ratio (LR) and 0.59 negative LR. The manufacturer's cut-off for peak tryptase was >11.4 µg/L with 17% sensitivity, 100% specificity, infinity positive LR and 0.83 negative LR. The best cut-off for delta-tryptase was ≥0.8 µg/L with 83% sensitivity, 93% specificity, 11.86 positive LR and 0.18 negative LR. The best cut-off for tryptase ratio was ≥1.5 with 92% sensitivity, 96% specificity, 23 positive LR and 0.08 negative LR.
conclusionsThe peak tryptase level should be compared with the baseline value to confirm anaphylaxis. The tryptase ratio provide the best sensitivity, specificity, positive and negative LR than a single peak serum tryptase for the confirmation of shrimp-induced anaphylaxis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.