ArticleBeilstein journal of organic chemistry2014
Synthesis of the first examples of iminosugar clusters based on cyclopeptoid cores.
Article in Beilstein journal of organic chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- A Convenient Strategy to Access Diverse Libraries of Amphiphilic Compounds Based on Glycopeptoids.Chirality · 2026Article
- Carbon-based glyco-nanoplatforms: towards the next generation of glycan-based multivalent probes.Chemical Society reviews · 2022Review
- Macrocyclic Triazolopeptoids: A Promising Class of Extended Cyclic Peptoids.Organic letters · 2022Article
- Synthesis and Glycosidase Inhibition Properties of Calix[8]arene-Based Iminosugar Click Clusters.Pharmaceuticals (Basel, Switzerland) · 2020Article
- Cyclic Octamer Peptoids: Simplified Isosters of Bioactive Fungal Cyclodepsipeptides.Molecules (Basel, Switzerland) · 2018Article
- Recent Advances in the Synthesis of Peptoid Macrocycles.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Review
- Nanotechnology in Glycomics: Applications in Diagnostics, Therapy, Imaging, and Separation Processes.Medicinal research reviews · 2017Review
- Design, synthesis and photochemical properties of the first examples of iminosugar clusters based on fluorescent cores.Beilstein journal of organic chemistry · 2015Article
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Authors and funding
7 authors.
Funding
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Abstract
Cyclic N-propargyl α-peptoids of various sizes were prepared by way of macrocyclizations of linear N-substituted oligoglycines. These compounds were used as molecular platforms to synthesize a series of iminosugar clusters with different valency and alkyl spacer lengths by means of Cu(I)-catalysed azide-alkyne cycloadditions. Evaluation of these compounds as α-mannosidase inhibitors led to significant multivalent effects and further demonstrated the decisive influence of scaffold rigidity on binding affinity enhancements.
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Registered trials
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