ArticleBeilstein journal of organic chemistry2014
Asymmetric Ugi 3CR on isatin-derived ketimine: synthesis of chiral 3,3-disubstituted 3-aminooxindole derivatives.
Article in Beilstein journal of organic chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Enantiopure β-isocyano-boronic esters: synthesis and exploitation in isocyanide-based multicomponent reactions.Molecular diversity · 2023Article
- Two decades of recent advances of Ugi reactions: synthetic and pharmaceutical applications.RSC advances · 2020Review
- Isonitrile-Based Multicomponent Synthesis of β-Amino Boronic Acids as β-Lactamase Inhibitors.Antibiotics (Basel, Switzerland) · 2020Article
- Allylation of isatin-derived N-Boc-hydrazones followed by Pd-catalyzed carboamination reaction: an entry to 3-spiro-pyrazolidyl-oxindoles.RSC advances · 2019Article
- One step access to oxindole-based β-lactams through Ugi four-center three-component reaction.RSC advances · 2018Article
- Post-Ugi Cyclization for the Construction of Diverse Heterocyclic Compounds: Recent Updates.Frontiers in chemistry · 2018Review
- Complementary isonitrile-based multicomponent reactions for the synthesis of diversified cytotoxic hemiasterlin analogues.Organic & biomolecular chemistry · 2015Article
- Multicomponent Synthesis and Biological Evaluation of a Piperazine-Based Dopamine Receptor Ligand Library.ACS medicinal chemistry letters · 2015Article
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5 authors.
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Abstract
An efficient Ugi three-component reaction of a preformed chiral ketimine derived from isatin with various isonitrile and acid components has been developed. The reactions proceeded smoothly and in a stereocontrolled manner with regard to the new center of the Ugi products due to the stereoinduction of the amine chiral residue. A wide variety of novel chiral 3,3-disubstituted 3-aminooxindoles were obtained, a selection of which were subjected to post-Ugi transformations, paving the way to application as peptidomimetics.
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