ArticleGenetics2014
High-resolution mapping of two types of spontaneous mitotic gene conversion events in Saccharomyces cerevisiae.
Article in Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Detection of "hidden" mitotic crossovers by long-read DNA sequencing.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Improved genotype inference reveals cis- and trans-driven variation in the loss-of-heterozygosity rates in yeast.Genetics · 2026Article
- Contrasting mutation patterns in haploid and diploid cells from two yeast species.bioRxiv : the preprint server for biology · 2025Article
- The dynamics of loss of heterozygosity events in genomes.EMBO reports · 2025Review
- Hybrid adaptation is hampered by Haldane's sieve.Nature communications · 2024Article
- Exploiting phenotypic heterogeneity to improve production of glutathione by yeast.Microbial cell factories · 2024Article
- Splitting the yeast centromere by recombination.Nucleic acids research · 2024Article
- Loss of Heterozygosity Spectrum Depends on Ploidy Level in Natural Yeast Populations.Molecular biology and evolution · 2022Article
- Mitotic recombination in yeast: what we know and what we don't know.Current opinion in genetics & development · 2021Review
- Chromosome-level genome assembly reveals homologous chromosomes and recombination in asexual rotiferScience advances · 2021Article
- Noncanonical outcomes of break-induced replication produce complex, extremely long-tract gene conversion events in yeast.G3 (Bethesda, Md.) · 2021Article
- Loss of heterozygosity results in rapid but variable genome homogenization across yeast genetic backgrounds.eLife · 2021Article
- The neutral rate of whole-genome duplication varies among yeast species and their hybrids.Nature communications · 2021Article
- Mitotic gene conversion can be as important as meiotic conversion in driving genetic variability in plants and other species without early germline segregation.PLoS biology · 2021Article
- Homologous Recombination Subpathways: A Tangle to Resolve.Frontiers in genetics · 2021Review
- Genomic signatures of recombination in a natural population of the bdelloid rotifer Adineta vaga.Nature communications · 2020Article
- Genome-wide mapping of spontaneous genetic alterations in diploid yeast cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Trajectory and uniqueness of mutational signatures in yeast mutators.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Loss of Heterozygosity and Base Mutation Rates Vary AmongG3 (Bethesda, Md.) · 2020Article
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4 authors.
Funding
Abstract
Gene conversions and crossovers are related products of the repair of double-stranded DNA breaks by homologous recombination. Most previous studies of mitotic gene conversion events have been restricted to measuring conversion tracts that are <5 kb. Using a genetic assay in which the lengths of very long gene conversion tracts can be measured, we detected two types of conversions: those with a median size of ∼6 kb and those with a median size of >50 kb. The unusually long tracts are initiated at a naturally occurring recombination hotspot formed by two inverted Ty elements. We suggest that these long gene conversion events may be generated by a mechanism (break-induced replication or repair of a double-stranded DNA gap) different from the short conversion tracts that likely reflect heteroduplex formation followed by DNA mismatch repair. Both the short and long mitotic conversion tracts are considerably longer than those observed in meiosis. Since mitotic crossovers in a diploid can result in a heterozygous recessive deleterious mutation becoming homozygous, it has been suggested that the repair of DNA breaks by mitotic recombination involves gene conversion events that are unassociated with crossing over. In contrast to this prediction, we found that ∼40% of the conversion tracts are associated with crossovers. Spontaneous mitotic crossover events in yeast are frequent enough to be an important factor in genome evolution.
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