Evidence map›Paper›PMID 24990951›Full record

ArticleThe Journal of biological chemistry2014

Structure of the type IX group B Streptococcus capsular polysaccharide and its evolutionary relationship with types V and VII.

Francesco Berti, Edmondo Campisi, Chiara Toniolo, Laura Morelli, Stefano Crotti, Roberto Rosini, Maria Rosaria Romano, Vittoria Pinto, Barbara Brogioni, Giulia Torricelli and 3 more

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
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  5. Review
  6. Article
  7. Review
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  9. Article
  10. Article
  11. Article
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  13. Article
  14. A Vaccine Against Group BInfection and drug resistance · 2020
    Review
  15. Synthesis of a dimer of the repeating unit of type Ia Group BOrganic chemistry frontiers : an international journal of organic chemistry · 2019
    Article
  16. Article
  17. Surface Structures of Group BMicrobiology spectrum · 2019
    Review
  18. Article
  19. Article
  20. Progress toward a group B streptococcal vaccine.Human vaccines & immunotherapeutics · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Francesco BertiFrom Novartis Vaccines Research, 53100 Siena, Italy francesco.berti@novartis.com.
Edmondo CampisiFrom Novartis Vaccines Research, 53100 Siena, Italy.
Chiara TonioloFrom Novartis Vaccines Research, 53100 Siena, Italy.
Laura MorelliFrom Novartis Vaccines Research, 53100 Siena, Italy.
Stefano CrottiFrom Novartis Vaccines Research, 53100 Siena, Italy.
Roberto RosiniFrom Novartis Vaccines Research, 53100 Siena, Italy.
Maria Rosaria RomanoFrom Novartis Vaccines Research, 53100 Siena, Italy.
Vittoria PintoFrom Novartis Vaccines Research, 53100 Siena, Italy.
Barbara BrogioniFrom Novartis Vaccines Research, 53100 Siena, Italy.
Giulia TorricelliFrom Novartis Vaccines Research, 53100 Siena, Italy.
Robert JanulczykFrom Novartis Vaccines Research, 53100 Siena, Italy.
Guido GrandiFrom Novartis Vaccines Research, 53100 Siena, Italy.
Immaculada MargaritFrom Novartis Vaccines Research, 53100 Siena, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Group B Streptococcus capsular polysaccharide type IX was isolated and purified, and the structure of its repeating unit was determined. Type IX capsule → 4)[NeupNAc-α-(2 → 3)-Galp-β-(1 → 4)-GlcpNAc-β-(1 → 6)]-β-GlcpNAc-(1 → 4)-β-Galp-(1 → 4)-β-Glcp-(1 → appears most similar to types VII and V, although it contains two GlcpNAc residues. Genetic analysis identified differences in cpsM, cpsO, and cpsI gene sequences as responsible for the differentiation between the three capsular polysaccharide types, leading us to hypothesize that type V emerged from a recombination event in a type IX background.

Indexed as

Evolution, MolecularBase SequenceCarbohydrate ConformationCarbohydrate SequenceDNA PrimersGenes, BacterialMolecular Sequence DataNuclear Magnetic Resonance, BiomolecularPolymerase Chain ReactionPolymorphism, GeneticPolysaccharides, BacterialStreptococcus agalactiaeDNA PrimersPolysaccharides, BacterialBacterial GeneticsCapsular PolysaccharideGroup B StreptococcusNuclear Magnetic ResonancePolysaccharideStreptococcusVaccine

Identifiers

PMID24990951
PMCPMC4156066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.