Evidence map›Paper›PMID 2499095›Full record

ArticleVirchows Archiv. A, Pathological anatomy and histopathology1989

Increased expression of HLA-DR antigen on alveolar macrophages in pulmonary diseases.

W Popp, O Braun, H Zwick, H Rauscher, L Ritschka

Abstract read
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In one paragraph

Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

W PoppPulmonary Department, KH Lainz, Vienna, Austria.
O Braun
H Zwick
H Rauscher
L Ritschka
Klinik Hietzing · ATUniversity of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The expression of HLA-DR antigen on alveolar macrophages obtained by bronchoalveolar lavage in healthy controls and patients with different diseases was investigated, using cytofluorographic analysis and phykoerythrin conjugated monoclonal mouse anti-human HLA-DR antibody. Alveolar macrophages in patients with extrinsic allergic alveolitis (n = 4), idiopathic lung fibrosis (n = 4), sarcoidosis (n = 6), rheumatoid lung disease (n = 6) and pulmonary infection (n = 5) showed increased density of HLA-DR antigen expression compared to healthy control subjects (n = 5). The increased expression of HLA-DR antigen on alveolar macrophages confirms the importance of these cells for recognition of antigens and immunological responses in different pulmonary diseases.

Indexed as

Bronchoalveolar Lavage FluidCell CountFlow CytometryFluorescent Antibody TechniqueHLA-DR AntigensHumansLung DiseasesMacrophagesPulmonary AlveoliHLA-DR Antigens

Identifiers

PMID2499095
OpenAlexW1974455247

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.