ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Sleep deprivation disrupts prepulse inhibition and induces psychosis-like symptoms in healthy humans.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- Sleep and schizophrenia: From epiphenomenon to treatable causal target.Schizophrenia research · 2020Pooled it
- The role of sleep dysfunction in the occurrence of delusions and hallucinations: A systematic review.Clinical psychology review · 2015Pooled it
- Disrupting Sleep: The Effects of Sleep Loss on Psychotic Experiences Tested in an Experimental Study With Mediation Analysis.Schizophrenia bulletin · 2018Trial
- Prepulse inhibition of the blink reflex in functional neurological disorder and fibromyalgia.Brain : a journal of neurology · 2026Article
- Targeting Sleep to Improve Outcomes in Psychosis: Digital and Non-Pharmacological Interventions.Medicina (Kaunas, Lithuania) · 2026Review
- Sleep deprivation impairs information processing via dysregulation of chloride homeostasis in the prefrontal cortex.bioRxiv : the preprint server for biology · 2026Article
- Neurocognition After Perturbed Sleep (NAPS): A Protocol for an Experimental Study Examining the Impact of Sleep on Neurocognition, Functioning, and Clinical Indicators in People with Schizophrenia.medRxiv : the preprint server for health sciences · 2025Article
- Circadian rhythmicity in prepulse inhibition of the acoustic startle response: A study of chronotype and time-of-day effects in young healthy adults.Journal of psychopharmacology (Oxford, England) · 2025Article
- Sleep duration and its associated factors in schizophrenia patients: a large-scale cross-sectional survey.BMC psychiatry · 2025Article
- Sleep Matters in Chronotype and Mental Health Association: Evidence from the UK and Germany.Brain sciences · 2024Article
- Associations between disturbed sleep and attenuated psychotic experiences in people at clinical high risk for psychosis.Psychological medicine · 2024Article
- Baseline prepulse inhibition dependency of orexin A and REM sleep deprivation.Psychopharmacology · 2024Article
- Insomnia moderates the association between psychotic-like experiences and suicidal ideation in a non-clinical population: a network analysis.European archives of psychiatry and clinical neuroscience · 2024Article
- The dynamic relationship between sleep and psychotic experiences across the early stages of the psychosis continuum.Psychological medicine · 2023Article
- Sleep Deprivation Induces Dopamine System Maladaptation and Escalated Corticotrophin-Releasing Factor Signaling in Adolescent Mice.Molecular neurobiology · 2023Article
- Pedunculopontine-induced cortical decoupling as the neurophysiological locus of dissociation.Psychological review · 2023Article
- Self-Reported Sleep Quality Across Age Modulates Resting-State Functional Connectivity in Limbic and Fronto-Temporo-Parietal Networks: An Exploratory Cross-Sectional fMRI Study.Frontiers in aging neuroscience · 2022Article
- Categorical versus dimensional models of early psychosis.Early intervention in psychiatry · 2022Article
- Examining self-reported social functioning, sleep quality, and psychotic-like experiences in college students.Journal of psychiatric research · 2021Article
- Sleep Abnormalities in Schizophrenia: State of the Art and Next Steps.The American journal of psychiatry · 2021Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Translational biomarkers, such as prepulse inhibition (PPI) of the acoustic startle response, are playing an increasingly important role in the development of antipsychotic drugs for schizophrenia and related conditions. However, attempts to reliably induce a PPI deficit by psychotomimetic drugs have not been successful, leaving an unmet need for a cross-species psychosis model sensitive to this widely studied surrogate treatment target. Sleep deprivation (SD) might be such a model as it has previously been shown to induce PPI deficits in rats, which could be selectively prevented with antipsychotic but not anxiolytic or antidepressant compounds. Here, in a first proof-of-concept study we tested whether SD induces a deficit in PPI and an increase in psychosis-like symptoms in healthy humans. In two counterbalanced sessions, acoustic PPI and self-reported psychosis-like symptoms (Psychotomimetic States Inventory) were measured in 24 healthy human volunteers after a normal night's sleep and after a night of total SD. SD decreased PPI (p = 0.001) without affecting the magnitude or habituation of the startle response (all p > 0.13). SD also induced perceptual distortions, cognitive disorganization, and anhedonia (all p < 0.02). Thus, extending previous rodent work, we conclude that SD, in combination with the PPI biomarker, might be a promising translational surrogate model for psychosis as this method represents a possibility to partially and reversibly mimic the pathogenesis of psychotic states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.