Evidence map›Paper›PMID 24990928›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014

MeCP2 repression of G9a in regulation of pain and morphine reward.

Zhi Zhang, Wenjuan Tao, Yuan-Yuan Hou, Wei Wang, Paul J Kenny, Zhizhong Z Pan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Review
  2. Article
  3. Sex-specific role of the 5-HTNature communications · 2025
    Article
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  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Epigenetic Modulation of Opioid Receptors by Drugs of Abuse.International journal of molecular sciences · 2022
    Review
  17. Comprehensive Volumetric Analysis ofFrontiers in neuroscience · 2022
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhi ZhangDepartment of Anesthesiology and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, Key Laboratory of Brain Functions and Diseases, School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, China, and.ORCID http://orcid.org/0000-0002-4205-3181
Wenjuan TaoKey Laboratory of Brain Functions and Diseases, School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, China, and.
Yuan-Yuan HouDepartment of Anesthesiology and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030.
Wei WangDepartment of Anesthesiology and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030.
Paul J KennyDepartment of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Zhizhong Z PanDepartment of Anesthesiology and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, zzpan@mdanderson.org.

Funding

Role of MicroRNAs in the Mechanisms of Drug DependenceR01DA025983 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI KENNY, PAUL J. · 2008 to 2020
$4.0M
Synaptic mechanisms for interactions of chronic pain and opioid addictionR01DA027541 · NIDA · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PAN, ZHIZHONG Z. · 2009 to 2013
$1.7M
Delta-Opioid Receptor Trafficking and Pain InhibitionR01DA023069 · NIDA · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PAN, ZHIZHONG Z. · 2008 to 2012
$1.5M
NIDA NIH HHS DA023069NIDA NIH HHS DA025983NIDA NIH HHS DA027541NIDA NIH HHS R01 DA023069NIDA NIH HHS R01 DA025983NIDA NIH HHS R01 DA027541
6 · The paper itself

Abstract

Opioids are commonly used for pain relief, but their strong rewarding effects drive opioid misuse and abuse. How pain affects the liability of opioid abuse is unknown at present. In this study, we identified an epigenetic regulating cascade activated by both pain and the opioid morphine. Both persistent pain and repeated morphine upregulated the transcriptional regulator MeCP2 in mouse central nucleus of the amygdala (CeA). Chromatin immunoprecipitation analysis revealed that MeCP2 bound to and repressed the transcriptional repressor histone dimethyltransferase G9a, reducing G9a-catalyzed repressive mark H3K9me2 in CeA. Repression of G9a activity increased expression of brain-derived neurotrophic factor (BDNF). Behaviorally, persistent inflammatory pain increased the sensitivity to acquiring morphine-induced, reward-related behavior of conditioned place preference in mice. Local viral vector-mediated MeCP2 overexpression, Cre-induced G9a knockdown, and CeA application of BDNF mimicked, whereas MeCP2 knockdown inhibited, the pain effect. These results suggest that MeCP2 directly represses G9a as a shared mechanism in central amygdala for regulation of emotional responses to pain and opioid reward, and for their behavioral interaction.

Indexed as

RewardAmygdalaAnimalsBrain-Derived Neurotrophic FactorChronic PainConditioning, ClassicalCrosses, GeneticDisease SusceptibilityDown-RegulationEmotionsEpigenesis, GeneticExploratory BehaviorFemaleGene Expression RegulationGene Knockdown TechniquesGenetic VectorsBrain-Derived Neurotrophic FactorG9a protein, mouseHistone-Lysine N-MethyltransferaseMecp2 protein, mouseMethyl-CpG-Binding Protein 2MorphineNarcoticsNerve Tissue ProteinsRecombinant Fusion ProteinsG9aMeCP2opioidpainreward

Identifiers

PMID24990928
PMCPMC4078085

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.