ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Online stimulus optimization rapidly reveals multidimensional selectivity in auditory cortical neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Rethinking hierarchy: the auditory system as an integrated cortical-subcortical network.Nature reviews. Neuroscience · 2026Review
- Layer 5 and 6b extratelencephalic neurons encode distinct sound features in auditory cortex.bioRxiv : the preprint server for biology · 2026Article
- Aging in the Primary Auditory Cortex.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
- Function of the auditory cortex characterized by its intrinsic dynamic coactivation patterns estimated in individuals.bioRxiv : the preprint server for biology · 2025Article
- Bidirectional generative adversarial representation learning for natural stimulus synthesis.Journal of neurophysiology · 2024Article
- Functional Connectivity of the Auditory Cortex in Women With Trauma-Related Disorders Who Hear Voices.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- A stable sensory map emerges from a dynamic equilibrium of neurons with unstable tuning properties.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Reversible Inactivation of Ferret Auditory Cortex Impairs Spatial and Nonspatial Hearing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Choice-related activity and neural encoding in primary auditory cortex and lateral belt during feature-selective attention.Journal of neurophysiology · 2021Article
- Individual Variability in Functional Organization of the Human and Monkey Auditory Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Optimizing optogenetic stimulation protocols in auditory corticofugal neurons based on closed-loop spike feedback.Journal of neural engineering · 2019Article
- Sparse Representation in Awake Auditory Cortex: Cell-type Dependence, Synaptic Mechanisms, Developmental Emergence, and Modulation.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Subthreshold Activity Underlying the Diversity and Selectivity of the Primary Auditory Cortex Studied by Intracellular Recordings in Awake Marmosets.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Article
- Neural encoding of sensory and behavioral complexity in the auditory cortex.Current opinion in neurobiology · 2018Review
- Recent advances in understanding the auditory cortex.F1000Research · 2018Review
- Adaptive Stimulus Design for Dynamic Recurrent Neural Network Models.Frontiers in neural circuits · 2018Article
- Representations of Time-Varying Cochlear Implant Stimulation in Auditory Cortex of Awake Marmosets (The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- L-type calcium channels refine the neural population code of sound level.Journal of neurophysiology · 2016Article
- The Automatic Neuroscientist: A framework for optimizing experimental design with closed-loop real-time fMRI.NeuroImage · 2016Article
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4 authors.
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Abstract
Neurons in sensory brain regions shape our perception of the surrounding environment through two parallel operations: decomposition and integration. For example, auditory neurons decompose sounds by separately encoding their frequency, temporal modulation, intensity, and spatial location. Neurons also integrate across these various features to support a unified perceptual gestalt of an auditory object. At higher levels of a sensory pathway, neurons may select for a restricted region of feature space defined by the intersection of multiple, independent stimulus dimensions. To further characterize how auditory cortical neurons decompose and integrate multiple facets of an isolated sound, we developed an automated procedure that manipulated five fundamental acoustic properties in real time based on single-unit feedback in awake mice. Within several minutes, the online approach converged on regions of the multidimensional stimulus manifold that reliably drove neurons at significantly higher rates than predefined stimuli. Optimized stimuli were cross-validated against pure tone receptive fields and spectrotemporal receptive field estimates in the inferior colliculus and primary auditory cortex. We observed, from midbrain to cortex, increases in both level invariance and frequency selectivity, which may underlie equivalent sparseness of responses in the two areas. We found that onset and steady-state spike rates increased proportionately as the stimulus was tailored to the multidimensional receptive field. By separately evaluating the amount of leverage each sound feature exerted on the overall firing rate, these findings reveal interdependencies between stimulus features as well as hierarchical shifts in selectivity and invariance that may go unnoticed with traditional approaches.
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