ArticleScientific reports2014
Horizontal gene transfer of a bacterial insect toxin gene into the Epichloë fungal symbionts of grasses.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 57 citations in OpenAlex.
- Review
- Increasing Prevalence of Plant-Fungal Symbiosis Across Two Centuries of Environmental Change.Global change biology · 2025Article
- Study of the Correlation Between Endophyte Abundances and Metabolite Levels in Different Parts of the Tissue of Cultivated and WildMolecules (Basel, Switzerland) · 2025Article
- Effects and molecular mechanism of endophytic elicitors on the accumulation of secondary metabolites in medicinal plants.Frontiers in microbiology · 2025Review
- Article
- Anti-herbivory defences delivered by Epichloë fungal endophytes: a quantitative review of alkaloid concentration variation among hosts and plant parts.Annals of botany · 2024Review
- Characterization of microbial community assembly in parasitic plant systems and the influence of microorganisms on metabolite accumulation in parasitic plants: case study ofFrontiers in microbiology · 2024Article
- Horizontally Transferred DNA in the Genome of the Fungus Pyricularia oryzae is Associated With Repressive Histone Modifications.Molecular biology and evolution · 2023Article
- Genetic Diversity ofJournal of fungi (Basel, Switzerland) · 2022Article
- Telomere-to-Telomere Genome Sequences across a Single Genus Reveal Highly Variable Chromosome Rearrangement Rates but Absolute Stasis of Chromosome Number.Journal of fungi (Basel, Switzerland) · 2022Article
- Cross-species transcriptomics identifies core regulatory changes differentiating the asymptomatic asexual and virulent sexual life cycles of grass-symbiotic Epichloë fungi.G3 (Bethesda, Md.) · 2022Article
- Fungus-originated glucanase and monooxygenase genes in creeping bent grass (Agrostis stolonifera L.).PloS one · 2021Article
- Functional horizontal gene transfer from bacteria to eukaryotes.Nature reviews. Microbiology · 2018Review
- Partitioning of Fungal Endophyte Assemblages in Root-Parasitic PlantFrontiers in microbiology · 2018Article
- Identification of the fungal endophyte ofPeerJ · 2018Article
- Horizontal transfer of a ß-1,6-glucanase gene from an ancestral species of fungal endophyte to a cool-season grass host.Scientific reports · 2017Article
- The Epichloë festucae antifungal protein has activity against the plant pathogen Sclerotinia homoeocarpa, the causal agent of dollar spot disease.Scientific reports · 2017Article
- Genomic Data Quality Impacts Automated Detection of Lateral Gene Transfer in Fungi.G3 (Bethesda, Md.) · 2017Article
- Multiple horizontal transfers of nuclear ribosomal genes between phylogenetically distinct grass lineages.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Endophytic Epichloë species and their grass hosts: from evolution to applications.Plant molecular biology · 2016Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Horizontal gene transfer is recognized as an important factor in genome evolution, particularly when the newly acquired gene confers a new capability to the recipient species. We identified a gene similar to the makes caterpillars floppy (mcf1 and mcf2) insect toxin genes in Photorhabdus, bacterial symbionts of nematodes, in the genomes of the Epichloë fungi, which are intercellular symbionts of grasses. Infection by Epichloë spp. often confers insect resistance to the grass hosts, largely due to the production of fungal alkaloids. A mcf-like gene is present in all of the Epichloë genome sequences currently available but in no other fungal genomes. This suggests the Epichloë genes were derived from a single lineage-specific HGT event. Molecular dating was used to estimate the time of the HGT event at between 7.2 and 58.8 million years ago. The mcf-like coding sequence from Epichloë typhina subsp. poae was cloned and expressed in Escherichia coli. E. coli cells expressing the Mcf protein were toxic to black cutworms (Agrotis ipsilon), whereas E. coli cells containing the vector only were non-toxic. These results suggest that the Epichloë mcf-like genes may be a component, in addition to the fungal alkaloids, of the insect resistance observed in Epichloë-infected grasses.
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