ArticleBMC infectious diseases2014
Predictors of pulmonary tuberculosis treatment outcomes in South Korea: a prospective cohort study, 2005-2012.
Article in BMC infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00341601 (A Natural History Study of Multidrug-Resistant Tuberculosis Strains and Host Susceptibility Genes in Korean Patients With Pulmonary Tuberculosis), which is not on this map. Cited by 48 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Natural History Study of Multidrug-Resistant Tuberculosis Strains and Host Susceptibility Genes in Korean Patients With Pulmonary Tuberculosis
Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- Factors predictive of the success of tuberculosis treatment: A systematic review with meta-analysis.PloS one · 2019Pooled it
- Pooled it
- Treatment and recurrence on re-treatment tuberculosis patients: a randomized clinical trial and 7-year perspective cohort study in China.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Trial
- Factors associated with extended treatment duration in patients with drug-susceptible pulmonary tuberculosis: a prospective multicentre cohort study in South Korea.BMC infectious diseases · 2026Article
- Clinical characteristics, drug resistance profiles, and inflammatory cytokine signatures in newly treated versus retreated MDR/RR-TB patients: associations with treatment outcomes.Frontiers in microbiology · 2026Article
- Impact of Nutritional Counselling and Support on Body Mass Index Recovery and Treatment Outcomes Among Tuberculosis Patients in the Lao People's Democratic Republic.Tropical medicine and infectious disease · 2025Article
- Treatment outcomes of pulmonary TB in adults in Indonesia.IJTLD open · 2025Article
- Identifying Predictors of Unfavorable Treatment Outcomes in Tuberculosis Patients.International journal of environmental research and public health · 2024Article
- Silicosis predicts drug resistance and retreatment among tuberculosis patients in India: a secondary data analysis from Khambhat, Gujarat (2006-2022).BMC pulmonary medicine · 2024Article
- Cohort study on association between catastrophic costs and unfavorable tuberculosis treatment outcomes among TB-HIV and TB-diabetes comorbid patients in India.BMC public health · 2024Article
- A mixed-methods study on impact of active case finding on pulmonary tuberculosis treatment outcomes in India.Archives of public health = Archives belges de sante publique · 2024Article
- Artificial intelligence-based radiographic extent analysis to predict tuberculosis treatment outcomes: a multicenter cohort study.Scientific reports · 2024Article
- Determinants of unsuccessful tuberculosis treatment outcome in Southwest Ethiopia regional state public hospitals, 2022: a multi-center case control study.Frontiers in public health · 2024Article
- Prediction of pulmonary tuberculosis treatment outcome in a sub-Saharan African context.Journal of public health in Africa · 2023Article
- Helper T cell bias following tuberculosis chemotherapy identifies opportunities for therapeutic vaccination to prevent relapse.NPJ vaccines · 2023Article
- Silicosis as a predictor of tuberculosis mortality and treatment failure and need for incorporation in differentiated TB care models in India.Archives of public health = Archives belges de sante publique · 2023Article
- [Treatment Outcomes among Drug-susceptible Patients with Tuberculosis in the Republic of Korea, 2019-2020].Jugan geon-gang gwa jilbyeong · 2023Article
- Article
- Risk of loss to follow-up among tuberculosis patients in South Korea: whom should we focus on?Frontiers in public health · 2023Observational
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
backgroundTuberculosis remains an important health concern in many countries. The aim of this study was to identify predictors of unfavorable outcomes at the end of treatment (EOT) and at the end of study (EOS; 40 months after EOT) in South Korea.
methodsNew or previously treated tuberculosis patients were recruited into a prospective observational cohort study at two hospitals in South Korea. To identify predictors of unfavorable outcomes at EOT and EOS, logistic regression analysis was performed.
resultsThe proportion of multidrug-resistant tuberculosis (MDR-TB) was 8.2% in new cases and 57.9% in previously treated cases. Of new cases, 68.6% were cured, as were 40.7% of previously treated cases. At EOT, diabetes, ≥3 previous TB episodes, ≥1 significant regimen change, and MDR-TB were significantly associated with treatment failure or death. At EOS, age ≥35, body-mass index (BMI) <18.5, diabetes, and MDR-TB were significantly associated with treatment failure, death, or relapse. Among cases that were cured at EOT, age ≥50 and a BMI <18.5 were associated with subsequent death or relapse during follow-up to EOS. Treatment interruption was associated with service sector employees or laborers, bilateral lesions on chest X-ray, and previous treatment failure or treatment interruption history.
conclusionsRisk factors for poor treatment outcomes at EOT and EOS include both patient factors (diabetes status, age, BMI) and disease factors (history of multiple previous treatment episodes, MDR-TB). In this longitudinal, observational cohort study, diabetes mellitus and MDR-TB were risk factors for poor treatment outcomes and relapse. Measures to help ensure that the first tuberculosis treatment episode is also the last one may improve treatment outcomes.
trial registrationClinicalTrials.gov ID: NCT00341601.
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