ArticleAngewandte Chemie (International ed. in English)2014
Development of multinuclear polymeric nanoparticles as robust protein nanocarriers.
Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Ternary Solid Dispersions as an Alternative Approach to Enhance Pharmacological Activity.Drug design, development and therapy · 2025Review
- Synthesis of β-Cyclodextrin@gold Nanoparticles and Its Application on Colorimetric Assays for Ascorbic Acid andBiosensors · 2024Article
- Protein-modified nanomaterials: emerging trends in skin wound healing.Discover nano · 2023Review
- Harnessing the Therapeutic Potential of Biomacromolecules through Intracellular Delivery of Nucleic Acids, Peptides, and Proteins.Advanced healthcare materials · 2022Review
- Enhancement of bioactivity, thermal stability and tumor retention by self-fused concatenation of green fluorescent protein.Biochemistry and biophysics reports · 2021Article
- Biosynthesis of silver nano-drug using3 Biotech · 2021Article
- Article
- Flame-Made Calcium Phosphate Nanoparticles with High Drug Loading for Delivery of Biologics.Molecules (Basel, Switzerland) · 2020Article
- Designing and Immunomodulating Multiresponsive Nanomaterial for Cancer Theranostics.Frontiers in chemistry · 2020Review
- Applications of Nanovaccines for Disease Prevention in Cattle.Frontiers in bioengineering and biotechnology · 2020Review
- Nanosized Delivery Systems for Therapeutic Proteins: Clinically Validated Technologies and Advanced Development Strategies.Frontiers in bioengineering and biotechnology · 2020Review
- Theranostics Applications of Nanoparticles in Cancer Immunotherapy.Medical sciences (Basel, Switzerland) · 2018Review
- Silica-Based Nanoparticles for Protein Encapsulation and Delivery.Nanomaterials (Basel, Switzerland) · 2018Article
- Combinatorial approaches in post-polymerization modification for rational development of therapeutic delivery systems.Acta biomaterialia · 2018Review
- Polycation-telodendrimer nanocomplexes for intracellular protein delivery.Colloids and surfaces. B, Biointerfaces · 2018Article
- HFrontiers in pharmacology · 2018Article
- Human Albumin Fragments Nanoparticles as PTX Carrier for Improved Anti-cancer Efficacy.Frontiers in pharmacology · 2018Article
- Polylactide-tethered prodrugs in polymeric nanoparticles as reliable nanomedicines for the efficient eradication of patient-derived hepatocellular carcinoma.Theranostics · 2018Article
- Targeted Nanotherapeutics Encapsulating Liver X Receptor Agonist GW3965 Enhance Antiatherogenic Effects without Adverse Effects on Hepatic Lipid Metabolism in LdlrAdvanced healthcare materials · 2017Article
- Evolution of macromolecular complexity in drug delivery systems.Nature reviews. Chemistry · 2017Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
One limitation of current biodegradable polymeric nanoparticles is their inability to effectively encapsulate and sustainably release proteins while maintaining protein bioactivity. Here we report the engineering of PLGA-polycation nanoparticles with a core-shell structure that act as a robust vector for the encapsulation and delivery of proteins and peptides. The optimized nanoparticles can load high amounts of proteins (>20 % of nanoparticles by weight) in aqueous solution without organic solvents through electrostatic interactions by simple mixing, thereby forming nanospheres in seconds with diameters <200 nm. The relationship between nanosphere size, surface charge, PLGA-polycation composition, and protein loading is also investigated. The stable nanosphere complexes contain multiple PLGA-polycation nanoparticles, surrounded by large amounts of protein. This study highlights a novel strategy for the delivery of proteins and other relevant molecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.