ArticleBipolar disorders2014
Bipolar I disorder and major depressive disorder show similar brain activation during depression.
Article in Bipolar disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 5 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 5 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Alterations in resting-state brain activity patterns following antidepressant treatment: insights from a coordinate-based meta-analysis.Psychological medicine · 2025Pooled it
- Neural correlates of implicit emotion regulation in mood and anxiety disorders: an fMRI meta-analytic review.Scientific reports · 2025Pooled it
- Altered brain activation during reward anticipation in bipolar disorder.Translational psychiatry · 2022Pooled it
- Abnormal neural activities in adults and youths with major depressive disorder during emotional processing: a meta-analysis.Brain imaging and behavior · 2021Pooled it
- Altered neural activities during emotion regulation in depression: a meta-analysis.Journal of psychiatry & neuroscience : JPNPooled it
- A Multi-Dimensional and Integrative Approach to Examining the High-Risk and Ultra-High-Risk Stages of Bipolar Disorder.EBioMedicine · 2015Trial
- Clinical and functional connectivity changes following the stanford accelerated intelligent neuromodulation therapy (SAINT) in bipolar I depression: A pilot study.Journal of mood and anxiety disorders · 2026Article
- Plasma copeptin is coupled to resting-state frontoinsular-subgenual alpha dynamics in major depression with comorbid post-traumatic stress disorder.Frontiers in endocrinology · 2026Article
- Dysbiosis and depression: A study of gut microbiota alterations and functional pathways in antidepressant-naïve mood disorder patients.Translational psychiatry · 2025Article
- Brain connectivity and transcriptional changes induced by rTMS in first-episode major depressive disorder.Translational psychiatry · 2025Article
- Electroencephalography-based endogenous phenotype of diagnostic transition from major depressive disorder to bipolar disorder.Scientific reports · 2024Article
- Provincial and connector qualities of somatosensory brain network hubs in bipolar disorder.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Discrepancy of social cognition between bipolar disorders and major depressive disorders.Brain and behavior · 2024Article
- Abnormal activation patterns in MT+ during visual motion perception in major depressive disorder.Frontiers in psychiatry · 2024Article
- Perceiving visual negative stimuli in schizophrenia and bipolar disorder: Meta-analytic evidence of a common altered thalamic-parahippocampal-basal ganglia circuit.Neuroimage. Reports · 2023Article
- A Double-Blind Randomized Trial to Investigate Mechanisms of Antidepressant-Related Dysfunctional Arousal in Depressed or Anxious Youth at Familial Risk for Bipolar Disorder.Journal of personalized medicine · 2022Article
- Graph Theory Analysis of the Cortical Functional Network During Sleep in Patients With Depression.Frontiers in physiology · 2022Article
- Machine learning algorithm performance evaluation in structural magnetic resonance imaging-based classification of pediatric bipolar disorders type I patients.Frontiers in computational neuroscience · 2022Article
- Calcium imaging reveals depressive- and manic-phase-specific brain neural activity patterns in a murine model of bipolar disorder: a pilot study.Translational psychiatry · 2021Article
- Abnormal Functional Connectivity of the Amygdala in Mild Cognitive Impairment Patients With Depression Symptoms Revealed by Resting-State fMRI.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectivesDespite different treatments and courses of illness, depressive symptoms appear similar in major depressive disorder (MDD) and bipolar I disorder (BP-I). This similarity of depressive symptoms suggests significant overlap in brain pathways underlying neurovegetative, mood, and cognitive symptoms of depression. These shared brain regions might be expected to exhibit similar activation in individuals with MDD and BP-I during functional magnetic resonance imaging (fMRI).
methodsfMRI was used to compare regional brain activation in participants with BP-I (n = 25) and MDD (n = 25) during a depressive episode as well as 25 healthy comparison (HC) participants. During the scans, participants performed an attentional task that incorporated emotional pictures.
resultsDuring the viewing of emotional images, subjects with BP-I showed decreased activation in the middle occipital gyrus, lingual gyrus, and middle temporal gyrus compared to both subjects with MDD and HC participants. During attentional processing, participants with MDD had increased activation in the parahippocampus, parietal lobe, and postcentral gyrus. However, among these regions, only the postcentral gyrus also showed differences between MDD and HC participants.
conclusionsNo differences in cortico-limbic regions were found between participants with BP-I and MDD during depression. Instead, the major differences occurred in primary and secondary visual processing regions, with decreased activation in these regions in BP-I compared to major depression. These differences were driven by abnormal decreases in activation seen in the participants with BP-I. Posterior activation changes are a common finding in studies across mood states in participants with BP-I.
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