ArticleBMC public health2014
Quality of life in individuals living with HIV/AIDS attending a public sector antiretroviral service in Cape Town, South Africa.
Article in BMC public health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Clinical determinants associated with quality of life for people who live with HIV/AIDS: a Meta-analysis.BMC health services research · 2019Pooled it
- Patient-Reported Outcomes in First-Line Antiretroviral Therapy: Results From NEAT001/ANRS143 Trial Comparing Darunavir/Ritonavir in Combination With Tenofovir/Emtricitabine or Raltegravir.Journal of acquired immune deficiency syndromes (1999) · 2018Trial
- HIV, multimorbidity, and health-related quality of life in rural KwaZulu-Natal, South Africa: A population-based study.PloS one · 2024Article
- Factors associated with health-related quality of life among people living with HIV in South Korea: Tobit regression analysis.PloS one · 2024Article
- Determinants of health-related quality of life in people with Human Immunodeficiency Virus, failing first-line treatment in Africa.Health and quality of life outcomes · 2023Article
- Factors affecting quality of life in adults with HIV: A local cross-sectional study.The South African journal of physiotherapy · 2023Article
- Determinants of health-related quality of life in young adults living with perinatally acquired HIV infection in Botswana.Southern African journal of HIV medicine · 2022Article
- Health-related quality of life and its predictors among adults living with HIV/AIDS and receiving antiretroviral therapy in Pakistan.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Article
- Health-related quality of life of patients with HIV/AIDS at a tertiary care teaching hospital in Ethiopia.Health and quality of life outcomes · 2021Article
- Expert consensus statement on the science of HIV in the context of criminal law.Journal of the International AIDS Society · 2018Article
- Quality of life assessment in musculo-skeletal health.Aging clinical and experimental research · 2018Review
- Determinants of excellent/good self-rated health among HIV positive individuals in South Africa: evidence from a 2012 nationally representative household survey.BMC public health · 2018Article
- Health related quality of life of HIV/AIDS patients on highly active anti-retroviral therapy at a university referral hospital in Ethiopia.BMC health services research · 2017Article
- Association among oral symptoms, oral health-related quality of life, and health-related quality of life in a sample of adults living with HIV/AIDS in Malaysia.BMC oral health · 2017Article
- Article
- Cervical Abnormalities in South African Women Living With HIV With High Screening and Referral Rates.Journal of global oncology · 2016Article
- Internalized HIV and Drug Stigmas: Interacting Forces Threatening Health Status and Health Service Utilization Among People with HIV Who Inject Drugs in St. Petersburg, Russia.AIDS and behavior · 2016Article
- A new questionnaire for measuring quality of life - the Stark QoL.Health and quality of life outcomes · 2015Article
- Reproductive health and lifestyle factors associated with health-related quality of life among perinatally HIV-infected adolescents in Uganda.Health and quality of life outcomes · 2015Article
- Relationship between CD4 count and quality of life over time among HIV patients in Uganda: a cohort study.Health and quality of life outcomes · 2015Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHealth related quality of life (HRQoL) is an important outcome helping to understand the impact of antiretroviral therapy (ART). We examined and compared the HRQoL in relation to ART status among HIV-infected patients in a public sector service in Cape Town, South Africa. In addition, we aimed to examine the relationship between ART status and HRQoL according to CD4 count strata.
methodsA cross sectional study sample of 903 HIV-infected patients who were categorized as not receiving ART (ART-naïve) or receiving first-line ART for > 6 months (ART). HRQoL outcomes were compared in the two groups. HRQoL was assessed using the EQ-5D (five domains) and Visual Analogue Scale (EQ-5D VAS).
resultsOf the total sample, 435 were categorised as ART naïve (76% women) and 468 were on ART (78% women). There were no significant associations between groups for most of the EQ-5D domains, however ART-naïve experienced a significantly greater problem with mobility than the ART group. Being ART-naïve (adjusted odds ratio (aOR) 3.08 95% confidence interval (CI) 1.63- 7.89) and obese 2.78 (95% CI 1.24- 6.22) were identified as predictors for increased mobility problems in multivariate analysis. In addition, receiving ART (5.61 difference; 95% CI 2.50 - 8.72) and having some source of income (4.76; 95% CI 1.63 -7.89) were identified as predictors for a higher EQ-5D VAS score. When grouped according to CD4 count strata, there were no significant difference between groups for most of the EQ-5D domains, however the ART-naïve group indicated having significantly greater problems under the CD4 count of >500 cells/μL in the anxiety/depression domain (22.4% vs 8.8%, p = 0.018) and significantly lower EQ-5D VAS scores under the CD4 counts of ≤ 200 cells/μL (median 80 (IQR 60-90) vs 90 (IQR 80-100), p = 0.0003) and 201-350 cells/μL (median 80 (IQR 70-90) vs 90 (80-100), p = 0.0004) compared to ART group.
conclusionsHRQoL (self-rated health state) was improved with ART use, including those with immunocompromised status, which may be relevant to the public sector ART program in South Africa.
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