ArticleHuman molecular genetics2014
Lack of CCM1 induces hypersprouting and impairs response to flow.
Article in Human molecular genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
- Cerebral cavernous malformations: epidemiology, molecular pathogenesis, diagnosis and therapy.Molecular biomedicine · 2026Review
- Focused ultrasound-microbubble treatment arrests the growth and formation of cerebral cavernous malformations.Nature biomedical engineering · 2025Article
- KRIT1 in vascular biology and beyond.Bioscience reports · 2024Review
- Magnetic Resonance Imaging of Mouse Cerebral Cavernomas Reveal Differential Lesion Progression and Variable Permeability to Gadolinium.Arteriosclerosis, thrombosis, and vascular biology · 2023Article
- KRIT1-mediated regulation of neutrophil adhesion and motility.The FEBS journal · 2023Article
- Case report: Thrombolysis in patients with acute ischemic stroke and cerebral cavernous malformation.Frontiers in neurology · 2023Article
- Cerebral Cavernous Malformation: From Mechanism to Therapy.Circulation research · 2021Review
- Novel Murine Models of Cerebral Cavernous Malformations.Angiogenesis · 2020Article
- Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.The Journal of experimental medicine · 2020Article
- NIR-II window tracking of hyperglycemia induced intracerebral hemorrhage in cerebral cavernous malformation deficient mice.Biomaterials science · 2020Article
- Cerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation.International journal of molecular sciences · 2020Review
- VEGF signalling enhances lesion burden in KRIT1 deficient mice.Journal of cellular and molecular medicine · 2020Article
- Identification of a Novel CCM1 Frameshift Mutation in a Chinese Han Family With Multiple Cerebral Cavernous Malformations.Frontiers in neuroscience · 2020Article
- Phenotypic characterization of murine models of cerebral cavernous malformations.Laboratory investigation; a journal of technical methods and pathology · 2019Article
- Vascular heterogeneity and specialization in development and disease.Nature reviews. Molecular cell biology · 2017Review
- Article
- The molecular basis of endothelial cell plasticity.Nature communications · 2017Review
- Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.Nature · 2016Article
- Article
- KLF4 is a key determinant in the development and progression of cerebral cavernous malformations.EMBO molecular medicine · 2016Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 6 countries.
Funding
Abstract
Cerebral cavernous malformation (CCM) is a disease of vascular malformations known to be caused by mutations in one of three genes: CCM1, CCM2 or CCM3. Despite several studies, the mechanism of CCM lesion onset remains unclear. Using a Ccm1 knockout mouse model, we studied the morphogenesis of early lesion formation in the retina in order to provide insight into potential mechanisms. We demonstrate that lesions develop in a stereotypic location and pattern, preceded by endothelial hypersprouting as confirmed in a zebrafish model of disease. The vascular defects seen with loss of Ccm1 suggest a defect in endothelial flow response. Taken together, these results suggest new mechanisms of early CCM disease pathogenesis and provide a framework for further study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.