ArticleEuropean journal of applied physiology2014
Acute hypoxic exercise does not alter post-exercise iron metabolism in moderately trained endurance athletes.
Article in European journal of applied physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Factors Influencing the Hepcidin Response to Exercise: An Individual Participant Data Meta-analysis.Sports medicine (Auckland, N.Z.) · 2023Pooled it
- Impact of Exercise in Hypoxia on Inflammatory Cytokines in Adults: A Systematic Review and Meta-analysis.Sports medicine - open · 2023Pooled it
- Association of Serum Hepcidin Levels with Aerobic and Resistance Exercise: A Systematic Review.Nutrients · 2021Pooled it
- Hepcidin response to three consecutive days of endurance training in hypoxia.European journal of applied physiology · 2021Trial
- The Effect of Vitamin DInternational journal of environmental research and public health · 2020Trial
- Impact of a single swimming session on inflammatory response and iron homeostasis in adolescent female athletes during the luteal phase.Scientific reports · 2025Article
- Acute physiological responses and muscle recovery in females: a randomised controlled trial of muscle damaging exercise in hypoxia.BMC sports science, medicine & rehabilitation · 2024Article
- Iron Status and Physical Performance in Athletes.Life (Basel, Switzerland) · 2023Review
- No effect of supplemented heat stress during an acute endurance exercise session in hypoxia on hepcidin regulation.European journal of applied physiology · 2020Article
- Resistance exercise causes greater serum hepcidin elevation than endurance (cycling) exercise.PloS one · 2020Article
- The Post-Exercise Inflammatory Response to Repeated-Sprint Running in Hypoxia.Journal of sports science & medicine · 2018Article
- Effects of an Acute Exercise Bout on Serum Hepcidin Levels.Nutrients · 2018Review
- Post-exercise serum hepcidin levels were unaffected by hypoxic exposure during prolonged exercise sessions.PloS one · 2017Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study measured the influence of acute hypoxic exercise on Interleukin-6 (IL-6), hepcidin, and iron biomarkers in athletes.
methodsIn a repeated measures design, 13 moderately trained endurance athletes performed 5 × 4 min intervals at 90 % of their peak oxygen consumption velocity (vVO2peak) in both normoxic [NORM, fraction of inspired oxygen (F IO2) = 0.2093, 15.3 ± 1.7 km h(-1)] and simulated hypoxic (HYP, F IO2 = 0.1450, 13.2 ± 1.5 km h(-1)) conditions. Venous blood samples were obtained pre-, post-, and 3 h post-exercise, and analysed for serum hepcidin, IL-6, ferritin, iron, soluble transferrin receptor (sTfR), and transferrin saturation.
resultsPeak heart rate was significantly lower in HYP compared with NORM (p = 0.01); however, the rating of perceived exertion was similar between trials (p = 0.24). Ferritin (p = 0.02), transferrin (p = 0.03), and IL-6 (p = 0.01) significantly increased immediately post-exercise in both conditions, but returned to baseline 3 h later. Hepcidin levels significantly increased in both conditions 3 h post-exercise (p = 0.05), with no significant differences between trials. A significant treatment effect was observed between trials for sTfR (p = 0.01), but not iron and transferrin saturation.
conclusionAcute exercise in hypoxia did not influence post-exercise IL-6 production, hepcidin activity or iron metabolism compared with exercise at the same relative intensity in normoxia. Hence, acute exercise performed at the same relative intensity in hypoxia poses no further risk to an athlete's iron status, as compared with exercise in normoxia.
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