ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
MicroRNA-32 inhibits osteosarcoma cell proliferation and invasion by targeting Sox9.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- Overexpression of miR-32 in Chinese hamster ovary cells increases production of Fc-fusion protein.AMB Express · 2023Article
- LncRNA ROR1-AS1 accelerates osteosarcoma invasion and proliferation through modulating miR-504.Aging · 2020Article
- LINC01410 accelerated the invasion and proliferation of osteosarcoma by sponging miR-3128.Aging · 2020Article
- miRNA signatures in childhood sarcomas and their clinical implications.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019Review
- Identification and validation of microRNAs and their targets expressed in osteosarcoma.Oncology letters · 2019Article
- Regulatory effects of microRNA‑184 on osteosarcoma via the Wnt/β‑catenin signaling pathway.Molecular medicine reports · 2018Article
- MicroRNA-216b regulated proliferation and invasion of non-small cell lung cancer by targeting SOX9.Oncology letters · 2018Article
- Upregulation of microRNA-32 is associated with tumorigenesis and poor prognosis in patients with hepatocellular carcinoma.Oncology letters · 2018Article
- miR-30a suppresses osteosarcoma proliferation and metastasis by downregulating MEF2D expression.OncoTargets and therapy · 2018Article
- Downregulation of miR-30a is associated with proliferation and invasion via targeting MEF2D in cervical cancer.Oncology letters · 2017Article
- MicroRNA-379 suppresses osteosarcoma progression by targeting PDK1.Journal of cellular and molecular medicine · 2017Article
- MicroRNA-32 promotes cell proliferation, migration and suppresses apoptosis in breast cancer cells by targeting FBXW7.Cancer cell international · 2017Article
- TIMP3 regulates osteosarcoma cell migration, invasion, and chemotherapeutic resistances.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Dysfunction of microRNA-32 regulates ubiquitin ligase FBXW7 in multiple myeloma disease.OncoTargets and therapy · 2016Article
- Upregulation of sex-determining region Y-box 9 (SOX9) promotes cell proliferation and tumorigenicity in esophageal squamous cell carcinoma.Oncotarget · 2015Article
- Tanshinones suppress AURKA through up-regulation of miR-32 expression in non-small cell lung cancer.Oncotarget · 2015Article
- MiR-32 induces cell proliferation, migration, and invasion in hepatocellular carcinoma by targeting PTEN.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Review of microRNA in osteosarcoma and chondrosarcoma.Medical oncology (Northwood, London, England) · 2015Review
- microRNA-377 suppresses the proliferation of human osteosarcoma MG-63 cells by targeting CDK6.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- miR-32 functions as a tumor suppressor and directly targets SOX9 in human non-small cell lung cancer.OncoTargets and therapy · 2015Article
Corrections and comments
- Retraction · 2017-04-20Compromised Peer Review · Investigation by Journal/Publisher · · Journal published by SAGE starting in 2017
- Retracted
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing reports suggest that discovery of microRNAs (miRNAs) might provide a novel therapeutical target for human cancers, including osteosarcoma. Previous studies have shown that miR-32 was dysregulated in breast and endometrial cancer. However, its biological roles in osteosarcoma remain unclear. In the current study, we found that miR-32 was significantly down-regulated in osteosarcoma tissues, compared with the adjacent normal tissues. In vitro studies further demonstrated that miR-32 mimics were able to suppress, while its antisense oligos promoted cell proliferation in Saos-2 and U2OS cells. At the molecular level, our data further revealed that expression of Sox9 was negatively regulated by miR-32. Therefore, our results identify an important role for miR-32 in the osteosarcoma through regulating Sox9 expression.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.