Evidence map›Paper›PMID 24989618›Full record

SynthesisBMJ open2014

Legislative, educational, policy and other interventions targeting physicians' interaction with pharmaceutical companies: a systematic review.

Lina Alkhaled, Lara Kahale, Hala Nass, Hneine Brax, Racha Fadlallah, Kamal Badr, Elie A Akl

Abstract readSystematic Review
In one paragraph

Synthesis in BMJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Interventions to reduce corruption in the health sector.The Cochrane database of systematic reviews · 2016
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  9. Ethical challenges in contemporary psychiatry: an overview and an appraisal of possible strategies and research needs.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lina AlkhaledFaculty of Medicine, Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
Lara KahaleFaculty of Health Sciences, American University of Beirut, Beirut, Lebanon.
Hala NassFaculty of Medicine, University of Damascus, Damascus, Syria.
Hneine BraxFaculty of Medicine, Université Saint Joseph, Beirut, Lebanon.
Racha FadlallahFaculty of Health Sciences, American University of Beirut, Beirut, Lebanon.
Kamal BadrDepartment of Internal Medicine, American University of Beirut, Beirut, Lebanon.
Elie A AklDepartment of Internal Medicine, American University of Beirut, Beirut, Lebanon Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada Department of Medicine, State University of New York at Buffalo, Buffalo, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPharmaceutical company representatives likely influence the prescribing habits and professional behaviour of physicians.

objectiveThe objective of this study was to systematically review the effects of interventions targeting practising physicians' interactions with pharmaceutical companies. ELIGIBILITY CRITERIA: We included observational studies, non-randomised controlled trials (non-RCTs) and RCTs evaluating legislative, educational, policy or other interventions targeting the interactions between physicians and pharmaceutical companies. DATA SOURCES: The search strategy included an electronic search of MEDLINE and EMBASE. Two reviewers performed duplicate and independent study selection, data abstraction and assessment of risk of bias. APPRAISAL AND SYNTHESIS

methodsWe assessed the risk of bias in each included study. We summarised the findings narratively because the nature of the data did not allow a meta-analysis to be conducted. We assessed the quality of evidence by outcome using the GRADE methodology.

resultsOf 11 189 identified citations, one RCT and three observational studies met the eligibility criteria. All four studies specifically targeted one type of interaction with pharmaceutical companies, that is, interactions with drug representatives. The RCT provided moderate quality evidence of no effect of a 'collaborative approach' between the pharmaceutical industry and a health authority. The three observational studies provided low quality evidence suggesting a positive effect of policies aiming to reduce interaction between physicians and pharmaceutical companies (by restricting free samples, promotional material, and meetings with pharmaceutical company representatives) on prescription behaviour. LIMITATIONS: We identified too few studies to allow strong conclusions.

conclusionsAvailable evidence suggests a potential impact of policies aiming to reduce interaction between physicians and drug representatives on physicians' prescription behaviour. We found no evidence concerning interventions affecting other types of interaction with pharmaceutical companies.

Indexed as

Drug IndustryInterprofessional RelationsPhysiciansPolicyConflict of interestDrug industryGift givingPharmaPhysicianPrimary care

Identifiers

PMID24989618
PMCPMC4091460

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.