Evidence map›Paper›PMID 24989603›Full record

ArticleJournal of clinical microbiology2014

Neurotropic astrovirus in cattle with nonsuppurative encephalitis in Europe.

Ilias G Bouzalas, Daniel Wüthrich, Julia Walland, Cord Drögemüller, Andreas Zurbriggen, Marc Vandevelde, Anna Oevermann, Rémy Bruggmann, Torsten Seuberlich

Open access · bronzeAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 129 citations in OpenAlex.

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  7. Bovine astrovirus and its role in lymphocytic encephalitis in cattle in Ontario, Canada, 1988-2019.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ilias G BouzalasDivision of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Daniel WüthrichInterfaculty Bioinformatics Unit, University of Bern, Bern, Switzerland Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Julia WallandDivision of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland.
Cord DrögemüllerInstitute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Andreas ZurbriggenDivision of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Marc VandeveldeDivision of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Anna OevermannDivision of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Rémy BruggmannInterfaculty Bioinformatics Unit, University of Bern, Bern, Switzerland Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Torsten SeuberlichDivision of Neurological Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland torsten.seuberlich@vetsuisse.unibe.ch.
University of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Encephalitis is a frequently diagnosed condition in cattle with neurological diseases. Many affected animals present with a nonsuppurative inflammatory reaction pattern in the brain. While this pattern supports a viral etiology, the causative pathogen remains unknown in a large proportion of cases. Using viral metagenomics, we identified an astrovirus (bovine astrovirus [BoAstV]-CH13) in the brain of a cow with nonsuppurative encephalitis. Additionally, BoAstV RNA was detected with reverse transcription-PCR and in situ hybridization in about one fourth (5/22 animals) of cattle with nonsuppurative encephalitis of unknown etiology. Viral RNA was found primarily in neurons and at the site of pathology. These findings support the notion that BoAstV infection is a common cause of encephalitis in cattle. Phylogenetically, BoAstV-CH13 was closely related to rare astrovirus isolates from encephalitis cases in animals and a human patient. Future research needs to be directed toward the pathogenic mechanisms, epidemiology, and potential cross-species transmission of these neurotropic astroviruses.

Indexed as

AnimalsAstroviridae InfectionsBrainCattleCattle DiseasesCluster AnalysisEncephalitis, ViralEuropeIn Situ HybridizationMamastrovirusMolecular Sequence DataNeuronsPhylogenyRetrospective StudiesReverse Transcriptase Polymerase Chain ReactionRNA, ViralRNA, Viral

Identifiers

PMID24989603
PMCPMC4313157
OpenAlexW2067623687

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.