Evidence map›Paper›PMID 24989488›Full record

ArticleCirculation research2014

Two strikes and you're out: gene-gene mutation interactions in HCM.

Gerald W Dorn, Elizabeth M McNally

Abstract readEditorialComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Dilated Cardiomyopathy: A Genetic Journey from Past to Future.International journal of molecular sciences · 2024
    Review
  3. MYH7 in cardiomyopathy and skeletal muscle myopathy.Molecular and cellular biochemistry · 2024
    Review
  4. Genetic Testing in Patients with Hypertrophic Cardiomyopathy.International journal of molecular sciences · 2021
    Review
  5. Article
  6. Clinical and Mechanistic Insights Into the Genetics of Cardiomyopathy.Journal of the American College of Cardiology · 2016
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Gerald W DornFrom the Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO (G.W.D.); and Institute for Cardiovascular Research, Department of Medicine, The University of Chicago, IL (E.M.M.). emcnally@medicine.bsd.uchicago.edu gdorn@dom.wustl.edu.
Elizabeth M McNallyFrom the Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO (G.W.D.); and Institute for Cardiovascular Research, Department of Medicine, The University of Chicago, IL (E.M.M.). emcnally@medicine.bsd.uchicago.edu gdorn@dom.wustl.edu.

Funding

Training and education CoreU54AR052646 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI MCNALLY, ELIZABETH M, SWEENEY, H LEE · 2005 to 2020
$24.1M
Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
NCATS NIH HHS UL1 TR000430NIAMS NIH HHS U54 AR052646
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Amino Acid SubstitutionMutation, MissensePoint MutationAnimalsCardiac MyosinsCardiomyopathy, Hypertrophic, FamilialHumansMyosin Heavy ChainsCardiac MyosinsMYH7 protein, humanMyosin Heavy ChainsEditorialsgeneticsmodels, animal

Identifiers

PMID24989488
PMCPMC4083473

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.