SynthesisAmerican journal of epidemiology2014
Maternal hyperlipidemia and the risk of preeclampsia: a meta-analysis.
Synthesis in American journal of epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
124 citing papers in PubMed, 5 syntheses or guidelines pooled it, 269 citations in OpenAlex.
- Towards the Development of a Conceptual Framework of the Determinants of Pre-Eclampsia: A Hierarchical Systematic Review of Biomarkers.BJOG : an international journal of obstetrics and gynaecology · 2026Pooled it
- Effects of lifestyle interventions on cardiovascular risk factors in South Asians: a systematic review and meta-analysis.BMJ open · 2022Pooled it
- Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis.PloS one · 2020Pooled it
- The association between HIV (treatment), pregnancy serum lipid concentrations and pregnancy outcomes: a systematic review.BMC infectious diseases · 2017Pooled it
- Pooled it
- Highly Atherogenic Lipid Particles are Associated with Preeclampsia After Successful Fertility Treatment for Obese Women who have Unexplained Infertility.Reproductive sciences (Thousand Oaks, Calif.) · 2023Trial
- Metabolic syndrome in obesity: treatment success and adverse pregnancy outcomes with ovulation induction in polycystic ovary syndrome.American journal of obstetrics and gynecology · 2021Trial
- Maternal preconception lipid profile and gestational lipid changes in relation to birthweight outcomes.Scientific reports · 2020Trial
- Lipoprotein turnover and possible remnant accumulation in preeclampsia: insights from the Freiburg Preeclampsia H.E.L.P.-apheresis study.Lipids in health and disease · 2018Trial
- Impact of lifestyle intervention for obese women during pregnancy on maternal metabolic and inflammatory markers.International journal of obesity (2005) · 2017Trial
- Trial
- BMI-Dependent Associations of the Estradiol-Linked Polymorphism rs117585797 of theLife (Basel, Switzerland) · 2026Article
- Ultrasound-derived fat fraction and automated point shear-wave elastography in diagnosing intrahepatic cholestasis of pregnancy and preeclampsia.BMC pregnancy and childbirth · 2026Article
- Maternal circulating lipid metabolic heterogeneity in preeclampsia: machine learning identifies clinically distinct subtypes.BMC pregnancy and childbirth · 2026Article
- Pre-pregnancy obesity, gestational weight gain, and their relationship with maternal lipid levels at delivery across racial and ethnic populations.American journal of physiology. Heart and circulatory physiology · 2026Article
- Pregestational Cardiometabolic Biomarkers and Future Hypertensive Disorders of Pregnancy.JAMA network open · 2026Article
- Excessive hypercholesterolemia in pregnancy impairs the cardiovascular health of the adult female and male offspring.Bioscience reports · 2026Article
- A novel two-sample Mendelian randomization framework integrating common and rare variants: application to assess the effect of HDL-C on preeclampsia risk.Briefings in bioinformatics · 2026Article
- Prediction of Pregnancy-Related Complications in Women of Advanced Maternal Age: A Nomogram Based on LASSO and Logistic Regression.International journal of women's health · 2026Article
- Immunometabolic Dysregulation in Preeclampsia: Emerging Roles of Inflammation, Insulin Resistance, Uric Acid, and the Gut Microbiome.Mediators of inflammation · 2026Review
64 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Published reports examining lipid levels during pregnancy and preeclampsia have been inconsistent. The objective of this meta-analysis was to test the association between preeclampsia and maternal total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), non-HDL-C, and triglyceride levels measured during pregnancy. We conducted a systematic search for studies published between the index date until July 2013 reporting maternal lipid levels in women with preeclampsia and normotensive pregnant women. Seventy-four studies met all eligibility criteria and were included in the meta-analysis. Weighted mean differences in lipid levels were calculated using a random-effects model. Statistical heterogeneity was investigated using the I(2) statistic. Meta-regression was used to identify sources of heterogeneity. Preeclampsia was associated with elevated total cholesterol, non-HDL-C, and triglyceride levels, regardless of gestational age at the time of blood sampling, and with lower levels of HDL-C in the third trimester. A marginal association was found with LDL-C levels. Statistical heterogeneity was detected in all analyses. Meta-regression analyses suggested that differences in body mass index (weight (kg)/height (m)(2)) across studies may be partially responsible for the heterogeneity in the triglyceride and LDL-C analyses. This systematic review and meta-analysis demonstrates that women who develop preeclampsia have elevated levels of total cholesterol, non-HDL-C, and triglycerides during all trimesters of pregnancy, as well as lower levels of HDL-C during the third trimester.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.