ArticleThe Journal of general virology2014
Pathogenic influenza B virus in the ferret model establishes lower respiratory tract infection.
Article in The Journal of general virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Updated A(H1N1)pdm09 influenza virus ferret infection model permits refined antiviral assessment using aerosol inhalation challenge.PLoS pathogens · 2026Article
- Review
- Dissemination of influenza B virus to the lower respiratory tract of mice is restricted by the interferon response.Journal of virology · 2024Article
- Natural Product-Derived Phytochemicals for Influenza A Virus (H1N1) Prevention and Treatment.Molecules (Basel, Switzerland) · 2024Review
- Key considerations to improve the normalization, interpretation and reproducibility of morbidity data in mammalian models of viral disease.Disease models & mechanisms · 2024Article
- A comprehensive review of influenza B virus, its biological and clinical aspects.Frontiers in microbiology · 2024Review
- Quantitative measurement of influenza virus transmission in animal model: an overview of current state.Biophysical reviews · 2023Review
- Review
- Development and Effects of Influenza Antiviral Drugs.Molecules (Basel, Switzerland) · 2021Review
- The Power of First Impressions: Can Influenza Imprinting during Infancy Inform Vaccine Design?Vaccines · 2020Review
- Original antigenic sin priming of influenza virus hemagglutinin stalk antibodies.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- A Guide for the Use of the Ferret Model for Influenza Virus Infection.The American journal of pathology · 2020Review
- Characterization of Influenza A and B Viruses Circulating in Southern China During the 2017-2018 Season.Frontiers in microbiology · 2020Article
- Article
- Review
- Seroprevalence of influenza D virus in selected sample groups of Irish cattle, sheep and pigs.Irish veterinary journal · 2019Article
- Nucleoprotein vaccine induces cross-protective cytotoxic T lymphocytes against both lineages of influenza B virus.Clinical and experimental vaccine research · 2019Article
- Article
- Novel Influenza D virus: Epidemiology, pathology, evolution and biological characteristics.Virulence · 2017Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Influenza B viruses have become increasingly more prominent during influenza seasons. Influenza B infection is typically considered a mild disease and receives less attention than influenza A, but has been causing 20 to 50 % of the total influenza incidence in several regions around the world. Although there is increasing evidence of mid to lower respiratory tract diseases such as bronchitis and pneumonia in influenza B patients, little is known about the pathogenesis of recent influenza B viruses. Here we investigated the clinical and pathological profiles of infection with strains representing the two current co-circulating B lineages (B/Yamagata and B/Victoria) in the ferret model. Specifically, we studied two B/Victoria (B/Brisbane/60/2008 and B/Bolivia/1526/2010) and two B/Yamagata (B/Florida/04/2006 and B/Wisconsin/01/2010) strain infections in ferrets and observed strain-specific but not lineage-specific pathogenicity. We found B/Brisbane/60/2008 caused the most severe clinical illness and B/Brisbane/60/2008 and the B/Yamagata strains instigated pathology in the middle to lower respiratory tract. Importantly, B/Brisbane/60/2008 established efficient lower respiratory tract infection with high viral burden. Our phylogenetic analyses demonstrate profound reassortment among recent influenza B viruses, which indicates the genetic make-up of B/Brisbane/60/2008 differs from the other strains. This may explain the pathogenicity difference post-infection in ferrets.
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