ArticlePloS one2014
Pre- and postnatal determinants of deciduous molar hypomineralisation in 6-year-old children. The generation R study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- An Evaluation of Food and Nutrient Intake among Pregnant Women in The Netherlands: A Systematic Review.Nutrients · 2023Pooled it
- Prenatal, perinatal and postnatal events associated with hypomineralized second primary molar: a systematic review with meta-analysis.Clinical oral investigations · 2021Pooled it
- Second primary molar hypomineralisation and drugs used during pregnancy and infancy. A systematic review.Clinical oral investigations · 2020Pooled it
- Food Consumption, Nutrient Intake and Status during the First 1000 days of Life in the Netherlands: a Systematic Review.Nutrients · 2019Pooled it
- Prenatal and birth-related risk factors for hypomineralised second primary molars: a prospective cohort study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Evaluation of Fractal and Radiomorphometric Measurements of Mandibular Bone Structure in Pediatric Patients With Molar Incisor Hypomineralization.International journal of paediatric dentistry · 2025Article
- Risk for molar incisor hypomineralization in children with hypomineralizations in the deciduous dentition: a case-control study on children from a Swiss suburban region.BMC oral health · 2025Article
- Knowledge, assessment and treatment of molar incisor hypomineralisation (MIH) among German dentists.Clinical oral investigations · 2025Article
- Prevalence of hypomineralised second primary molars and molar incisor hypomineralisation in patients with cleft lip and/or palate.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Article
- Association between multiple genetic polymorphisms and molar-incisor hypomineralization: a population-based study.Journal of applied oral science : revista FOB · 2025Article
- Hypomineralized primary teeth and their association with Molar Incisor Hypomineralization: a cross-sectional study.Brazilian oral research · 2025Article
- Prevalence of Hypomineralized Second Primary Molar in Shaanxi, China.Frontiers in public health · 2025Article
- Prevalence of hypomineralized second primary molars and association with socioeconomic characteristics and dental caries in a Brazilian population of preschoolers: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Article
- Dental Developmental Defects: A Pilot Study to Examine the Prevalence and Etiology in a Population of Children between 2 and 15 Years of Age.Dentistry journal · 2024Article
- Oral and craniofacial research in the Generation R study: an executive summary.Clinical oral investigations · 2023Article
- The Prevalence of Developmental Enamel Defects in Israeli Children and Its Association with Perinatal Conditions: A Cross-Sectional Study.Children (Basel, Switzerland) · 2023Article
- Etiology Study of Acquired Developmental Defects of Enamel and Their Association with Dental Caries in Children between 3 and 19 Years Old from Dolj County, Romania.Children (Basel, Switzerland) · 2022Article
- Factors and Mechanisms Involved in Acquired Developmental Defects of Enamel: A Scoping Review.Frontiers in pediatrics · 2022Article
- Caries experience among children born after a complicated pregnancy.Community dentistry and oral epidemiology · 2021Article
- Assessment of Genetical, Pre, Peri and Post Natal Risk Factors of Deciduous Molar Hypomineralization (DMH), Hypomineralized Second Primary Molar (HSPM) and Molar Incisor Hypomineralization (MIH): A Narrative Review.Children (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDeciduous Molar Hypomineralisation (DMH) and Molar Incisor Hypomineralisation (MIH) are common developmental disturbances in pediatric dentistry. Their occurrence is related. The same determinants as suggested for MIH are expected for DMH, though somewhat earlier in life. Perinatal medical problems may influence the prevalence of DMH but this has not been studied sufficiently.
objectiveThis study aimed to identify possible determinants of DMH in a prospective cohort study among 6-year-old children. STUDY
designThis study was embedded in the Generation R Study, a population-based prospective cohort study from fetal life until young adulthood. The the data were used to identify the determinants of DMH. Clinical photographs of clean, moist teeth were taken with an intra-oral camera in 6690 children (mean age 6.2 years; 49.9% girls). Data on possible determinants that had occurred during pregnancy and/or the child's first year of life were on the basis of manual standardized measurements (like length and weight) and questionnaires. Multivariate analyse with backward and forward selection was performed.
resultsA number of factors in the pre-, peri- and postnatal phase were found to be associated with DMH. After multivariate logistic regression analyses, Dutch ethnic background, low birth weight, maternal alcohol consumption during pregnancy, and fever episodes in the first year of the child's life were found to play a role in the development of DMH in 6-year-old children.
conclusionThis study shows that Dutch ethnicity, low birth weight, alcohol consumption by the mother during pregnancy and any fever in the first year of the child's life are associated with DMH. Not only childhood factors but also prenatal lifestyle factors need to be taken into account when studying determinants for DMH.
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