ArticlePloS one2014
Domain specific changes in cognition at high altitude and its correlation with hyperhomocysteinemia.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- High-altitude exposure alters the coupling among core large-scale brain networks: a multi-altitude rs-fMRI study.MedScience · 2026Article
- Detrimental Effects of Hypoxia on Cognitive Function: Adaptations, Challenges, and Resilience in Andean Populations.Journal of racial and ethnic health disparities · 2025Article
- A review of methods for assessment of cognitive function in high-altitude hypoxic environments.Brain and behavior · 2024Review
- Effect of aqueous extract of Astragalus membranaceus on behavioral cognition of rats living at high altitude.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2022Article
- Exosomal miRNA-223-3p as potential biomarkers in patients with cerebral small vessel disease cognitive impairment.Annals of translational medicine · 2021Article
- Electrophysiological mechanisms underlying hypoxia-induced deficits in visual spatial and non-spatial discrimination.Physiological reports · 2021Article
- Altered resting-state networks may explain the executive impairment in young health immigrants into high-altitude area.Brain imaging and behavior · 2021Article
- Hypobaria-Induced Oxidative Stress Facilitates Homocysteine Transsulfuration and Promotes Glutathione Oxidation in Rats with Mild Traumatic Brain Injury.Journal of central nervous system disease · 2021Article
- Phenolic Acids-Rich Fractions fromMolecules (Basel, Switzerland) · 2020Article
- Hyperbaric oxygen ameliorates cognitive impairment in patients with Alzheimer's disease and amnestic mild cognitive impairment.Alzheimer's & dementia (New York, N. Y.) · 2020Article
- Conscious Abstinence from Smokeless Tobacco Evokes Higher Withdrawal Response and Impairs Cognitive Performance Independent of Sympathetic Response.Annals of neurosciences · 2020Article
- Aging of stimulus-driven and goal-directed attentional processes in young immigrants with long-term high altitude exposure in Tibet: An ERP study.Scientific reports · 2018Article
- Prevalence and risk factors of hypertension in acclimatized lowlanders staying at high altitude for different durations.Journal of human hypertension · 2018Article
- The influence of hypoxia and prolonged exercise on attentional performance at high and extreme altitudes: A pilot study.PloS one · 2018Article
- Cognitive Changes during Prolonged Stay at High Altitude and Its Correlation with C-Reactive Protein.PloS one · 2016Article
- Different Effects of Hypoxia on Mental Rotation of Normal and Mirrored Letters: Evidence from the Rotation-Related Negativity.PloS one · 2016Article
- The Impact of Different Environmental Conditions on Cognitive Function: A Focused Review.Frontiers in physiology · 2015Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Though acute exposure to hypobaric hypoxia is reported to impair cognitive performance, the effects of prolonged exposure on different cognitive domains have been less studied. The present study aimed at investigating the time dependent changes in cognitive performance on prolonged stay at high altitude and its correlation with electroencephalogram (EEG) and plasma homocysteine. The study was conducted on 761 male volunteers of 25-35 years age who had never been to high altitude and baseline data pertaining to domain specific cognitive performance, EEG and homocysteine was acquired at altitude ≤240 m mean sea level (MSL). The volunteers were inducted to an altitude of 4200-4600 m MSL and longitudinal follow-ups were conducted at durations of 03, 12 and 18 months. Neuropsychological assessment was performed for mild cognitive impairment (MCI), attention, information processing rate, visuo-spatial cognition and executive functioning. Total homocysteine (tHcy), vitamin B12 and folic acid were estimated. Mini Mental State Examination (MMSE) showed temporal increase in the percentage prevalence of MCI from 8.17% on 03 months of stay at high altitude to 18.54% on 18 months of stay. Impairment in visuo-spatial executive, attention, delayed recall and procedural memory related cognitive domains were detected following prolonged stay in high altitude. Increase in alpha wave amplitude in the T3, T4 and C3 regions was observed during the follow-ups which was inversely correlated (r = -0.68) to MMSE scores. The tHcy increased proportionately with duration of stay at high altitude and was correlated with MCI. No change in vitamin B12 and folic acid was observed. Our findings suggest that cognitive impairment is progressively associated with duration of stay at high altitude and is correlated with elevated tHcy in the plasma. Moreover, progressive MCI at high altitude occurs despite acclimatization and is independent of vitamin B12 and folic acid.
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