ArticleBiophysical journal2014
A G-protein subunit translocation embedded network motif underlies GPCR regulation of calcium oscillations.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- G Protein-Coupled Receptors in Cerebrovascular Diseases: Signaling Mechanisms and Therapeutic Opportunities.International journal of molecular sciences · 2026Review
- Phytophthora zoospores display klinokinetic behaviour in response to a chemoattractant.PLoS pathogens · 2024Article
- Molecular regulation of PLCβ signaling.Methods in enzymology · 2023Review
- Subtype-dependent regulation of Gβγ signalling.Cellular signalling · 2021Review
- Live Cell Imaging and Optogenetics-Based Assays for GPCR Activity.Methods in molecular biology (Clifton, N.J.) · 2021Article
- GPCR mediated control of calcium dynamics: A systems perspective.Cellular signalling · 2020Review
- Optical approaches for single-cell and subcellular analysis of GPCR-G protein signaling.Analytical and bioanalytical chemistry · 2019Review
- When trafficking and signaling mix: How subcellular location shapes G protein-coupled receptor activation of heterotrimeric G proteins.Traffic (Copenhagen, Denmark) · 2019Review
- Two independent but synchronized Gβγ subunit-controlled pathways are essential for trailing-edge retraction during macrophage migration.The Journal of biological chemistry · 2017Article
- Optogenetic approaches for dissecting neuromodulation and GPCR signaling in neural circuits.Current opinion in pharmacology · 2017Review
- Band-pass processing in a GPCR signaling pathway selects for NFAT transcription factor activation.Integrative biology : quantitative biosciences from nano to macro · 2015Article
- Ca2+ signaling in cytoskeletal reorganization, cell migration, and cancer metastasis.BioMed research international · 2015Review
- Dissociation of the G protein βγ from the Gq-PLCβ complex partially attenuates PIP2 hydrolysis.The Journal of biological chemistryArticle
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
G-protein βγ subunits translocate reversibly from the plasma membrane to internal membranes on receptor activation. Translocation rates differ depending on the γ subunit type. There is limited understanding of the role of the differential rates of Gβγ translocation in modulating signaling dynamics in a cell. Bifurcation analysis of the calcium oscillatory network structure predicts that the translocation rate of a signaling protein can regulate the damping of system oscillation. Here, we examined whether the Gβγ translocation rate regulates calcium oscillations induced by G-protein-coupled receptor activation. Oscillations in HeLa cells expressing γ subunit types with different translocation rates were imaged and quantitated. The results show that differential Gβγ translocation rates can underlie the diversity in damping characteristics of calcium oscillations among cells. Mathematical modeling shows that a translocation embedded motif regulates damping of G-protein-mediated calcium oscillations consistent with experimental data. The current study indicates that such a motif may act as a tuning mechanism to design oscillations with varying damping patterns by using intracellular translocation of a signaling component.
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