ArticleJournal of studies on alcohol and drugs2014
Alcohol consumption mediates the relationship between ADH1B and DSM-IV alcohol use disorder and criteria.
Article in Journal of studies on alcohol and drugs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Alcohol consumption and risk for Parkinson's disease: a systematic review and meta-analysis.Journal of neurology · 2019Pooled it
- Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts.The American journal of psychiatry · 2019Pooled it
- Association between alcohol consumption and mortality in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Genetic risk for alcohol use disorder in relation to individual symptom criteria: Do polygenic indices provide unique information for understanding severity and heterogeneity?Addiction (Abingdon, England) · 2025Article
- Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria.Genes, brain, and behavior · 2019Article
- Association between the missense alcohol dehydrogenase rs1229984T variant with the risk for Parkinson's disease in women.Journal of neurology · 2019Article
- Which alcohol use disorder criteria contribute to the association of ADH1B with alcohol dependence?Addiction biology · 2016Article
- Nosologic Comparisons of DSM-IV and DSM-5 Alcohol and Drug Use Disorders: Results From the National Epidemiologic Survey on Alcohol and Related Conditions-III.Journal of studies on alcohol and drugs · 2015Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectiveA single nucleotide variation in the alcohol dehydrogenase 1B (ADH1B) gene, rs1229984, produces an ADH1B enzyme with faster acetaldehyde production. This protective variant is associated with lower alcohol consumption and lower risk for alcohol use disorders (AUDs). Based on the premise that faster ADH1B kinetics decreases alcohol consumption, we formally tested if the association between ADH1B variant rs1229984 and AUDs occurs through consumption. We also tested whether the association between rs1229984 and each of the 11 Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), AUD criteria occurs through consumption.
methodA total of 1,130 lifetime drinkers from an Israeli household sample were assessed with a structured interview and genotyped for rs1229984 (protective allele frequency = 0.28). Logistic regression evaluated the association between rs1229984 and each phenotype (AUDs, 11 individual DSM-IV criteria). For phenotypes significantly related to rs1229984, the effect through consumption was tested with logistic regression and bootstrapping.
resultsADH1B rs1229984 was significantly associated with AUDs and six criteria, with odds ratios ranging from 1.32 to 1.96. The effect through consumption was significant for these relationships, explaining 23%-74% of the total ADH1B effect.
conclusionsThis is the first study to show that ADH1B rs1229984 is related to 6 of the 11 DSM-IV AUD criteria and that alcohol consumption explained a significant proportion of these associations and the association of ADH1B with AUDs. Better understanding of the relationship between ADH1B and the DSM-IV AUD criteria, including effects through consumption, will enhance our understanding of the etiologic model through which AUDs can occur.
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