Evidence map›Paper›PMID 24988074›Full record

ArticlePloS one2014

The effect of the hemochromatosis (HFE) genotype on lead load and iron metabolism among lead smelter workers.

Guangqin Fan, Guihua Du, Huijun Li, Fen Lin, Ziyong Sun, Wei Yang, Chang Feng, Gaochun Zhu, Yanshu Li, Ying Chen and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. HFE H63D Limits Nigral Vulnerability to Paraquat in Agricultural Workers.Toxicological sciences : an official journal of the Society of Toxicology · 2021
    Article
  6. Interactive Effects between Chronic Lead Exposure and the Homeostatic Iron Regulator TransportInternational journal of environmental research and public health · 2019
    Article
  7. Childhood Lead Exposure and Adult Neurodegenerative Disease.Journal of Alzheimer's disease : JAD · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Guangqin FanDepartment of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang, People's Republic of China.
Guihua DuDepartment of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang, People's Republic of China.
Huijun LiDepartment of clinical laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Fen LinDepartment of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang, People's Republic of China; Department of Preventive Medicine, School of Medicine, Gannan Medicine University, Ganzhou, People's Republic of China.
Ziyong SunDepartment of clinical laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Wei YangNevada Center for Health Statistics and Informatics, School of Community Health Sciences, University of Nevada, Reno, United States of America.
Chang FengDepartment of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang, People's Republic of China.
Gaochun ZhuDepartment of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang, People's Republic of China.
Yanshu LiDepartment of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang, People's Republic of China.
Ying ChenDepartment of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang, People's Republic of China.
Huan JiaoDepartment of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang, People's Republic of China.
Fankun ZhouDepartment of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang, People's Republic of China.
Nanchang University · CNTongji Hospital · CNGannan Medical University · CNUniversity of Nevada, Reno · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBoth an excess of toxic lead (Pb) and an essential iron disorder have been implicated in many diseases and public health problems. Iron metabolism genes, such as the hemochromatosis (HFE) gene, have been reported to be modifiers for lead absorption and storage. However, the HFE gene studies among the Asian population with occupationally high lead exposure are lacking.

objectivesTo explore the modifying effects of the HFE genotype (wild-type, H63D variant and C282Y variant) on the Pb load and iron metabolism among Asian Pb-workers with high occupational exposure.

methodsSeven hundred and seventy-one employees from a lead smelter manufacturing company were tested to determine their Pb intoxication parameters, iron metabolic indexes and identify the HFE genotype. Descriptive and multivariate analyses were conducted.

resultsForty-five H63D variant carriers and no C282Y variant carrier were found among the 771 subjects. Compared with subjects with the wild-type genotype, H63D variant carriers had higher blood lead levels, even after controlling for factors such as age, sex, marriage, education, smoking and lead exposure levels. Multivariate analyses also showed that the H63D genotype modifies the associations between the blood lead levels and the body iron burden/transferrin.

conclusionsNo C282Y variant was found in this Asian population. The H63D genotype modified the association between the lead and iron metabolism such that increased blood lead is associated with a higher body iron content or a lower transferrin in the H63D variant. It is indicated that H63D variant carriers may be a potentially highly vulnerable sub-population if they are exposed to high lead levels occupationally.

Indexed as

AdultFemaleGenotypeHemochromatosisHemochromatosis ProteinHistocompatibility Antigens Class IHumansIronLeadLead PoisoningMaleMembrane ProteinsOccupational ExposurePoint MutationYoung AdultHemochromatosis ProteinHFE protein, humanHistocompatibility Antigens Class IIronLeadMembrane Proteins

Identifiers

PMID24988074
PMCPMC4079697
OpenAlexW2061363706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.