ReviewBioMed research international2014
6-[18F]fluoro-L-DOPA: a well-established neurotracer with expanding application spectrum and strongly improved radiosyntheses.
Review in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Protective Group-Dependent Iridium-Catalyzed CH Borylations of Levodopa.The Journal of organic chemistry · 2025Article
- Copper-mediated radiochemistry: historical impact, current trends, and future possibilities.Npj imaging · 2025Review
- Evaluation of Neurodegenerative Disorders with Amyloid-β, Tau, and Dopaminergic PET Imaging: Interpretation Pitfalls.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Review
- Imaging of Pain using Positron Emission Tomography.iRadiology · 2024Article
- Development of the FirstPharmaceutics · 2023Article
- Radiosynthesis, Preclinical, and Clinical Positron Emission Tomography Studies of Carbon-11 Labeled Endogenous and Natural Exogenous Compounds.Chemical reviews · 2023Review
- Automatic Production of [Pharmaceuticals (Basel, Switzerland) · 2022Article
- Experience of 6-l-[Nuclear medicine and molecular imaging · 2022Article
- Nucleophilic Radiofluorination Using Tri-Molecules (Basel, Switzerland) · 2022Article
- Arene radiofluorination enabled by photoredox-mediated halide interconversion.Nature chemistry · 2022Article
- The role of the deep convolutional neural network as an aid to interpreting brain [European radiology · 2021Article
- GMP production of 6-[EJNMMI radiopharmacy and chemistry · 2021Article
- Advances in the automated synthesis of 6-[EJNMMI radiopharmacy and chemistry · 2021Review
- Direct Radiofluorination of Arene C-H Bonds via Photoredox Catalysis Using a Peroxide as the Terminal Oxidant.Organic letters · 2020Article
- Nucleophilic Synthesis of 6-l-[Molecules (Basel, Switzerland) · 2020Review
- Synthesis of high-molar-activity [Nature protocols · 2020Article
- Harnessing Ionic Interactions and Hydrogen Bonding for Nucleophilic Fluorination.Molecules (Basel, Switzerland) · 2020Review
- Green and efficient synthesis of the radiopharmaceutical [Reaction chemistry & engineering · 2020Article
- One-pot synthesis of high molar activity 6-[Organic & biomolecular chemistry · 2019Article
- Direct arene C-H fluorination withScience (New York, N.Y.) · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For many years, the main application of [(18)F]F-DOPA has been the PET imaging of neuropsychiatric diseases, movement disorders, and brain malignancies. Recent findings however point to very favorable results of this tracer for the imaging of other malignant diseases such as neuroendocrine tumors, pheochromocytoma, and pancreatic adenocarcinoma expanding its application spectrum. With the application of this tracer in neuroendocrine tumor imaging, improved radiosyntheses have been developed. Among these, the no-carrier-added nucleophilic introduction of fluorine-18, especially, has gained increasing attention as it gives [(18)F]F-DOPA in higher specific activities and shorter reaction times by less intricate synthesis protocols. The nucleophilic syntheses which were developed recently are able to provide [(18)F]F-DOPA by automated syntheses in very high specific activities, radiochemical yields, and enantiomeric purities. This review summarizes the developments in the field of [(18)F]F-DOPA syntheses using electrophilic synthesis pathways as well as recent developments of nucleophilic syntheses of [(18)F]F-DOPA and compares the different synthesis strategies regarding the accessibility and applicability of the products for human in vivo PET tumor imaging.
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