ArticleBioMed research international2014
Morphological changes in the suprachiasmatic nucleus of aging female marmosets (Callithrix jacchus).
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Survival is reduced when endogenous period deviates from 24 h in a non-human primate, supporting the circadian resonance theory.Scientific reports · 2020Article
- A Standardized Extract ofNutrients · 2019Article
- Gene expression profiling of the SCN in young and old rhesus macaques.Journal of molecular endocrinology · 2018Article
- The Suprachiasmatic Nucleus and the Intergeniculate Leaflet of the Flat-Faced Fruit-Eating Bat (Frontiers in neuroanatomy · 2018Article
- Contributions of Nonhuman Primates to Research on Aging.Veterinary pathology · 2016Review
- Age-related changes in neurochemical components and retinal projections of rat intergeniculate leaflet.Age (Dordrecht, Netherlands) · 2016Article
- Thyroxine differentially modulates the peripheral clock: lessons from the human hair follicle.PloS one · 2015Article
- A hypothetic aging pathway from skin to hypothalamic suprachiasmatic nucleus via slow wave sleep.Sleep science (Sao Paulo, Brazil)Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The suprachiasmatic nuclei (SCN) are pointed to as the mammals central circadian pacemaker. Aged animals show internal time disruption possibly caused by morphological and neurochemical changes in SCN components. Some studies reported changes of neuronal cells and neuroglia in the SCN of rats and nonhuman primates during aging. The effects of senescence on morphological aspects in SCN are important for understanding some alterations in biological rhythms expression. Therefore, our aim was to perform a comparative study of the morphological aspects of SCN in adult and aged female marmoset. Morphometric analysis of SCN was performed using Nissl staining, NeuN-IR, GFAP-IR, and CB-IR. A significant decrease in the SCN cells staining with Nissl, NeuN, and CB were observed in aged female marmosets compared to adults, while a significant increase in glial cells was found in aged marmosets, thus suggesting compensatory process due to neuronal loss evoked by aging.
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