ReviewJournal of allergy2014
Thermal water applications in the treatment of upper respiratory tract diseases: a systematic review and meta-analysis.
Review in Journal of allergy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Beneficial effects of thermal waters on respiratory diseases: a systematic review.International journal of biometeorology · 2025Pooled it
- Clinical efficacy of medical hydrology: an umbrella review.International journal of biometeorology · 2021Pooled it
- Clinical and Mechanistic Evidence for Comano Thermal Water: A Narrative Review.International journal of molecular sciences · 2026Review
- Physical activity patterns and vaccination attitudes among thermal spa attendees: a cross-sectional study.BMC public health · 2026Article
- From catheterization to crenotherapy: historical and functional perspective on the Eustachian tube.European journal of translational myology · 2025Article
- A Novel Bionebulizer Approach to Study the Effects of Natural Mineral Water on a 3D In Vitro Nasal Model from Allergic Rhinitis Patients.Biomedicines · 2024Article
- Marked Reduction of Oxidant Species after Sulfureous Crenotherapy in Females with Joint Diseases and Psoriasis: A Retrospective Real-Life Study.Journal of clinical medicine · 2023Article
- Prevention of recurrent respiratory infections : Inter-society Consensus.Italian journal of pediatrics · 2021Article
- Hydrogen Sulfide Inhibits TMPRSS2 in Human Airway Epithelial Cells: Implications for SARS-CoV-2 Infection.Biomedicines · 2021Article
- Inhalations with Brine Solution from the 'Wieliczka' Salt Mine Diminish Airway Hyperreactivity and Inflammation in a Murine Model of Non-Atopic Asthma.International journal of molecular sciences · 2020Article
- Short- and long-term beneficial effects of medicinal mineral water administration.Environmental geochemistry and health · 2020Article
- Sulphurous thermal water inhalation impacts respiratory metabolic parameters in heavy smokers.International journal of biometeorology · 2019Article
- Broncalt®, class II medical device, in patients with acute upper airways disease: a survey in clinical practice.Acta bio-medica : Atenei Parmensis · 2019Article
- The nutraceuticals: a new therapeutic strategy in the management of digestive and respiratory disorders.Acta bio-medica : Atenei Parmensis · 2019Article
- Article
- Biological Effects of Thermal Water-Associated Hydrogen Sulfide on Human Airways and Associated Immune Cells: Implications for Respiratory Diseases.Frontiers in public health · 2019Review
- Gene and protein expression ofImmunity & ageing : I & A · 2018Article
- Sulphurous Mineral Waters: New Applications for Health.Evidence-based complementary and alternative medicine : eCAM · 2017Review
- Effects of thermal water inhalation in chronic upper respiratory tract infections in elderly and young patients.Immunity & ageing : I & A · 2016Article
- Radioactive Merano SPA Treatment for Allergic Rhinitis Therapy.International journal of otolaryngology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Thermal water inhalations and irrigations have a long tradition in the treatment of airway diseases. Currently there exists no systematic review or meta-analysis on the effectiveness of thermal water treatment in upper respiratory tract diseases. Methods. A systematic search in the databases of MEDLINE, EMBASE, CENTRAL, ISI Web of Science, and MedPilot was accomplished. Results. Eight evaluable outcome parameters from 13 prospective clinical studies were identified for 840 patients. Mucociliary clearance time improves significantly (P < 0.01) for the pooled thermal water subgroup and the sulphurous subgroup after 2 weeks (-6.69/minutes) and after 90 days (-8.33/minutes), not for isotonic sodium chloride solution (ISCS). Nasal resistance improved significantly after 2 weeks (Radon, ISCS, and placebo), after 30 days (sulphur and ISCS), and after 90 days (sulphur). Nasal flow improved significantly with the pooled thermal water, radon alone, and ISCS subgroups. For the IgE parameter only sulphurous thermal water (P < 0.01) and ISCS (P > 0.01) were analyzable. Adverse events of minor character were only reported for sulphurous treatment (19/370). Conclusion. Thermal water applications with radon or sulphur can be recommended as additional nonpharmacological treatment in upper airway diseases. Also in comparison to isotonic saline solution it shows significant improvements and should be investigated further.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.