ArticleFrontiers in physiology2014
The impact of flow-induced forces on the morphogenesis of the outflow tract.
Article in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Developmental and Evolutionary Heart Adaptations Through Structure-Function Relationships.Journal of cardiovascular development and disease · 2025Review
- Collagen Fibrillogenesis in the Mitral Valve: It's a Matter of Compliance.Journal of cardiovascular development and disease · 2021Review
- New Concepts in the Development and Malformation of the Arterial Valves.Journal of cardiovascular development and disease · 2020Review
- Cardiac function modulates endocardial cell dynamics to shape the cardiac outflow tract.Development (Cambridge, England) · 2020Article
- Validating the Paradigm That Biomechanical Forces Regulate Embryonic Cardiovascular Morphogenesis and Are Fundamental in the Etiology of Congenital Heart Disease.Journal of cardiovascular development and disease · 2020Review
- Follow Me! A Tale of Avian Heart Development with Comparisons to Mammal Heart Development.Journal of cardiovascular development and disease · 2020Review
- Organ Dynamics and Hemodynamic of the Whole HH25 Avian Embryonic Heart, Revealed by Ultrasound Biomicroscopy, Boundary Tracking, and Flow Simulations.Scientific reports · 2019Article
- Second harmonic generation microscopy of early embryonic mouse hearts.Biomedical optics express · 2019Article
- Quantifying blood flow dynamics during cardiac development: demystifying computational methods.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Influence of blood flow on cardiac development.Progress in biophysics and molecular biology · 2018Review
- Constitutive modeling of compressible type-I collagen hydrogels.Medical engineering & physics · 2018Article
- Removing vessel constriction on the embryonic heart results in changes in valve gene expression, morphology, and hemodynamics.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
- The Genetic Regulation of Aortic Valve Development and Calcific Disease.Frontiers in cardiovascular medicine · 2018Review
- Hemodynamics Modify Collagen Deposition in the Early Embryonic Chicken Heart Outflow Tract.Journal of cardiovascular development and disease · 2017Article
- Animal Models for Heart Valve Research and Development.Drug discovery today. Disease models · 2017Article
- Interplay between cardiac function and heart development.Biochimica et biophysica acta · 2016Review
- 4D subject-specific inverse modeling of the chick embryonic heart outflow tract hemodynamics.Biomechanics and modeling in mechanobiology · 2016Article
- A Novel Ex Ovo Banding Technique to Alter Intracardiac Hemodynamics in an Embryonic Chicken System.Journal of visualized experiments : JoVE · 2016Article
- Genetic and flow anomalies in congenital heart disease.AIMS genetics · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
One percent of infants are born with congenital heart disease (CHD), which commonly involves outflow tract (OFT) defects. These infants often require complex surgeries, which are associated with long term adverse remodeling effects, and receive replacement valves with limited strength, biocompatibility, and growth capability. To address these problematic issues, researchers have carried out investigations in valve development and valve mechanics. A longstanding hypothesis is that flow-induced forces regulate fibrous valve development, however, the specific mechanisms behind this mechanotransduction remain unclear. The purpose of this study was to implement an in vitro system of outflow tract development to test the response of embryonic OFT tissues to fluid flow. A dynamic, three-dimensional bioreactor system was used to culture embryonic OFT tissue under different levels of flow as well as the absence of flow. In the absence of flow, OFT tissues took on a more primitive phenotype that is characteristic of early OFT cushion development where widely dispersed mesenchymal cells are surrounded by a sparse, disorganized extracellular matrix (ECM). Whereas OFT tissues subjected to physiologically matched flow formed compact mounds of cells, initated, fibrous ECM development, while prolonged supraphysiological flow resulted in abnormal tissue remodeling. This study indicates that both the timing and magnitude of flow alter cellular processes that determine if OFT precursor tissue undergoes normal or pathological development. Specifically, these experiments showed that flow-generated forces regulate the deposition and localization of fibrous ECM proteins, indicating that mechanosensitive signaling pathways are capable of driving pathological OFT development if flows are not ideal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.