Evidence map›Paper›PMID 24987372›Full record

ArticleFrontiers in physiology2014

Skeletal muscle as a regulator of the longevity protein, Klotho.

Keith G Avin, Paul M Coen, Wan Huang, Donna B Stolz, Gwendolyn A Sowa, John J Dubé, Bret H Goodpaster, Robert M O'Doherty, Fabrisia Ambrosio

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Keith G AvinDepartment of Physical Medicine and Rehabilitation, University of Pittsburgh Pittsburgh, PA, USA ; Division of Geriatric Medicine, Department of Medicine, University of Pittsburgh PA, USA.
Paul M CoenDivision of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh Pittsburgh, PA, USA ; Department of Health and Physical Education, University of Pittsburgh Pittsburgh, PA, USA.
Wan HuangDepartment of Physical Medicine and Rehabilitation, University of Pittsburgh Pittsburgh, PA, USA.
Donna B StolzDepartment of Cell Biology and Physiology, University of Pittsburgh Pittsburgh, PA, USA.
Gwendolyn A SowaDepartment of Physical Medicine and Rehabilitation, University of Pittsburgh Pittsburgh, PA, USA.
John J DubéDivision of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh Pittsburgh, PA, USA.
Bret H GoodpasterDivision of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh Pittsburgh, PA, USA.
Robert M O'DohertyDivision of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh Pittsburgh, PA, USA.
Fabrisia AmbrosioDepartment of Physical Medicine and Rehabilitation, University of Pittsburgh Pittsburgh, PA, USA ; McGowan Institute for Regenerative Medicine, University of Pittsburgh Pittsburgh, PA, USA.
University of Pittsburgh · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
Electrical stimulation reverses the effect of age on skeletal muscle regenerationK01AG039477 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AMBROSIO, FABRISIA · 2011 to 2013
$325k
NCATS NIH HHS UL1 TR000005NIA NIH HHS K01 AG039477NIA NIH HHS P30 AG024827
6 · The paper itself

Abstract

Klotho is a powerful longevity protein that has been linked to the prevention of muscle atrophy, osteopenia, and cardiovascular disease. Similar anti-aging effects have also been ascribed to exercise and physical activity. While an association between muscle function and Klotho expression has been previously suggested from longitudinal cohort studies, a direct relationship between circulating Klotho and skeletal muscle has not been investigated. In this paper, we present a review of the literature and preliminary evidence that, together, suggests Klotho expression may be modulated by skeletal muscle activity. Our pilot clinical findings performed in young and aged individuals suggest that circulating Klotho levels are upregulated in response to an acute exercise bout, but that the response may be dependent on fitness level. A similar upregulation of circulating Klotho is also observed in response to an acute exercise in young and old mice, suggesting that this may be a good model for mechanistically probing the role of physical activity on Klotho expression. Finally, we highlight overlapping signaling pathways that are modulated by both Klotho and skeletal muscle and propose potential mechanisms for cross-talk between the two. It is hoped that this review will stimulate further consideration of the relationship between skeletal muscle activity and Klotho expression, potentially leading to important insights into the well-documented systemic anti-aging effects of exercise.

Indexed as

agingexerciseKlothoregenerationskeletal muscle

Identifiers

PMID24987372
PMCPMC4060456
OpenAlexW2034373988

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.