Evidence map›Paper›PMID 24987355›Full record

ArticleCase reports in oncology2014

Familial adenomatous polyposis in three generations of a single family: a case study.

Jure Murgic, Iva Kirac, Zeljko Soldic, Davor Tomas, Mario Zovak, Ante Bolanca, Andrzej Plawski, Y Banasiewicz, Zvonko Kusic

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Genetic background of supernumerary teeth.European journal of dentistry
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Jure MurgicDepartment of Oncology and Nuclear Medicine, University Hospital for Tumors, Croatia, Poland.
Iva KiracDepartment of Surgical Oncology, University Hospital for Tumors, Croatia, Poland.
Zeljko SoldicDepartment of Oncology and Nuclear Medicine, University Hospital for Tumors, Croatia, Poland.
Davor TomasLjudevit Jurak Department of Pathology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia, Poland.
Mario ZovakDepartment of Surgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia, Poland.
Ante BolancaDepartment of Oncology and Nuclear Medicine, University Hospital for Tumors, Croatia, Poland.
Andrzej PlawskiInstitute of Human Genetics, Polish Academy of Sciences, Poznań University of Medical Sciences, Poznań, Poland.
Y BanasiewiczDepartment of General Surgery, Poznań University of Medical Sciences, Poznań, Poland.
Zvonko KusicDepartment of Oncology and Nuclear Medicine, University Hospital for Tumors, Croatia, Poland.
University Hospital Centre Zagreb · HRSisters of Charity Hospital · HRInstitute of Plant Genetics, Polish Academy of Sciences · PLPoznan University of Medical Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFamilial adenomatous polyposis (FAP) is an autosomal dominantly inherited syndrome characterized by the development of numerous polyps in the colon and rectum. If left untreated, the affected patients inevitably develop colon cancer by the age of 40 years. A resection of the colon (colectomy) or of the colon and rectum (proctocolectomy) is needed to minimize the risk of cancer. CASE PRESENTATION: We report a case of FAP through three generations of a single family, in which the grandmother and granddaughter underwent total colectomy with ileoanal anastomosis and did not develop colon cancer, while the son underwent subtotal colectomy with ileorectal anastomosis and developed recurrent rectal cancer. Data regarding timely surgery, surveillance, and chemoprevention are discussed.

conclusionThe FAP phenotype determines the type of treatment. In severe polyposis, proctocolectomy with ileoanal anastomosis seems to be the optimal method for minimizing the risk of cancer development. This case report advocates complete rectal removal, especially in cases of poor patient compliance with colonoscopic surveillance.

Indexed as

2805C>G substitutionColectomyFamilial adenomatous polyposisRectal cancer

Identifiers

PMID24987355
PMCPMC4067724
OpenAlexW2065986339

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.