ArticleMediators of inflammation2014
Regulatory T cells protect fine particulate matter-induced inflammatory responses in human umbilical vein endothelial cells.
Article in Mediators of inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Protective role of tissue-resident Tregs in a murine model of beryllium-induced disease.JCI insight · 2022Article
- Influence of air pollutants on circulating inflammatory cells and microRNA expression in acute myocardial infarction.Scientific reports · 2022Article
- Near-roadway air pollution, immune cells and adipokines among obese young adults.Environmental health : a global access science source · 2022Article
- Serum peptidomic screening identified circulating peptide biomarkers predictive for preeclampsia.Frontiers in cardiovascular medicine · 2022Article
- Regulatory T Cells in Chronic Heart Failure.Frontiers in immunology · 2021Review
- Regulatory T cells ameliorate tissue plasminogen activator-induced brain haemorrhage after stroke.Brain : a journal of neurology · 2017Article
- Acute exposure to air pollution particulate matter aggravates experimental myocardial infarction in mice by potentiating cytokine secretion from lung macrophages.Basic research in cardiology · 2016Article
- Exposure to concentrated ambient fine particulate matter disrupts vascular endothelial cell barrier function via the IL-6/HIF-1α signaling pathway.FEBS open bio · 2016Article
- Blood-brain barrier dysfunction and recovery after ischemic stroke.Progress in neurobiologyReview
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the role of CD4(+)CD25(+) T cells (Tregs) in protecting fine particulate matter (PM-) induced inflammatory responses, and its potential mechanisms.
methodsHuman umbilical vein endothelial cells (HUVECs) were treated with graded concentrations (2, 5, 10, 20, and 40 µg/cm(2)) of suspension of fine particles for 24h. For coculture experiment, HUVECs were incubated alone, with CD4(+)CD25(-) T cells (Teff), or with Tregs in the presence of anti-CD3 monoclonal antibodies for 48 hours, and then were stimulated with or without suspension of fine particles for 24 hours. The expression of adhesion molecules and inflammatory cytokines was examined.
resultsAdhesion molecules, including vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1), and inflammatory cytokines, such as interleukin (IL-) 6 and IL-8, were increased in a concentration-dependent manner. Moreover, the adhesion of human acute monocytic leukemia cells (THP-1) to endothelial cells was increased and NF- κ B activity was upregulated in HUVECs after treatment with fine particles. However, after Tregs treatment, fine particles-induced inflammatory responses and NF- κ B activation were significantly alleviated. Transwell experiments showed that Treg-mediated suppression of HUVECs inflammatory responses impaired by fine particles required cell contact and soluble factors.
conclusionsTregs could attenuate fine particles-induced inflammatory responses and NF- κ B activation in HUVECs.
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