Evidence map›Paper›PMID 24987054›Full record

ArticleCirculation. Cardiovascular quality and outcomes2014

Prediction of 30-year risk for cardiovascular mortality by fitness and risk factor levels: the Cooper Center Longitudinal Study.

Chanaka D Wickramasinghe, Colby R Ayers, Sandeep Das, James A de Lemos, Benjamin L Willis, Jarett D Berry

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Circulation. Cardiovascular quality and outcomes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Relationship Between Cardiorespiratory Fitness, Baseline Blood Pressure and Hypertensive Response to Exercise in the Ferrari Corporate Population.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2022
    Article
  7. Review
  8. Article
  9. Article
  10. Aerobic capacity is associated with disease activity and cardiovascular risk factors in early rheumatoid arthritis.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2020
    Article
  11. Article
  12. Article
  13. Review
  14. Observational
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chanaka D WickramasingheFrom the Division of Cardiology, Department of Internal Medicine (C.D.W., S.D., J.A.d.L., J.D.B.) and Reynolds Cardiovascular Clinical Research Center (C.R.A.), University of Texas Southwestern Medical Center, Dallas; and Cooper Institute, Dallas, TX (B.L.W.).
Colby R AyersFrom the Division of Cardiology, Department of Internal Medicine (C.D.W., S.D., J.A.d.L., J.D.B.) and Reynolds Cardiovascular Clinical Research Center (C.R.A.), University of Texas Southwestern Medical Center, Dallas; and Cooper Institute, Dallas, TX (B.L.W.).
Sandeep DasFrom the Division of Cardiology, Department of Internal Medicine (C.D.W., S.D., J.A.d.L., J.D.B.) and Reynolds Cardiovascular Clinical Research Center (C.R.A.), University of Texas Southwestern Medical Center, Dallas; and Cooper Institute, Dallas, TX (B.L.W.).
James A de LemosFrom the Division of Cardiology, Department of Internal Medicine (C.D.W., S.D., J.A.d.L., J.D.B.) and Reynolds Cardiovascular Clinical Research Center (C.R.A.), University of Texas Southwestern Medical Center, Dallas; and Cooper Institute, Dallas, TX (B.L.W.).
Benjamin L WillisFrom the Division of Cardiology, Department of Internal Medicine (C.D.W., S.D., J.A.d.L., J.D.B.) and Reynolds Cardiovascular Clinical Research Center (C.R.A.), University of Texas Southwestern Medical Center, Dallas; and Cooper Institute, Dallas, TX (B.L.W.).
Jarett D BerryFrom the Division of Cardiology, Department of Internal Medicine (C.D.W., S.D., J.A.d.L., J.D.B.) and Reynolds Cardiovascular Clinical Research Center (C.R.A.), University of Texas Southwestern Medical Center, Dallas; and Cooper Institute, Dallas, TX (B.L.W.). jarett.berry@utsouthwestern.edu.

Funding

Magnetic Resonance Imaging of Carotid Artery Subclincal AtherosclerosisK23HL092229 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI BERRY, JARETT D · 2009 to 2013
$661k
NHLBI NIH HHS K23 HL092229
6 · The paper itself

Abstract

backgroundFitness and traditional risk factors have well-known associations with cardiovascular disease (CVD) death in both short-term (10 years) and across the remaining lifespan. However, currently available short-term and long-term risk prediction tools do not incorporate measured fitness. METHODS AND

resultsWe included 16 533 participants from the Cooper Center Longitudinal Study (CCLS) without prior CVD. Fitness was measured using the Balke protocol. Sex-specific fitness levels were derived from the Balke treadmill times and categorized into low, intermediate, and high fit according to age- and sex-specific treadmill times. Sex-specific 30-year risk estimates for CVD death adjusted for competing risk of non-CVD death were estimated using the cause-specific hazards model and included age, body mass index, systolic blood pressure, fitness, diabetes mellitus, total cholesterol, and smoking. During a median follow-up period of 28 years, there were 1123 CVD deaths. The 30-year risk estimates for CVD mortality derived from the cause-specific hazards model demonstrated overall good calibration (Nam-D'Agostino χ(2) [men, P=0.286; women, P=0.664] and discrimination (c statistic; men, 0.81 [0.80-0.82] and women, 0.86 [0.82-0.91]). Across all risk factor strata, the presence of low fitness was associated with a greater 30-year risk for CVD death.

conclusionsFitness represents an important additional covariate in 30-year risk prediction functions that may serve as a useful tool in clinical practice.

Indexed as

ForecastingPhysical FitnessAdultAgedAged, 80 and overCardiovascular DiseasesFemaleFollow-Up StudiesHumansMaleMiddle AgedRisk AssessmentRisk FactorsSurvival RateTexasYoung Adultcardiovascular diseasesmortalityrisk factors

Identifiers

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.