Evidence map›Paper›PMID 24987052›Full record

ArticleCirculation. Cardiovascular quality and outcomes2014

Center-level variation in infection rates after coronary artery bypass grafting.

Terry Shih, Min Zhang, Mallika Kommareddi, Theodore J Boeve, Steven D Harrington, Robert J Holmes, Gary Roth, Patricia F Theurer, Richard L Prager, Donald S Likosky and 1 more

Registry-linked trialOpen access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular quality and outcomes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02068716 (Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02068716 completednot on this map

Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery

TypeobservationalSponsorDr. Donald LikoskyRan2014 to 2018Enrolled911,754ConditionsHealthcare Associated Infectious Disease, Sternal Superficial Wound Infection, Sepsis, Pneumonia
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Life after Coronary Artery Bypass Grafting: Lifestyle Changes, Secondary Prevention, and Quality of Life.The International journal of angiology : official publication of the International College of Angiology, Inc · 2025
    Review
  3. Interhospital variability in 180-day infections following cardiac surgery.The Journal of thoracic and cardiovascular surgery · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Determinants of Value in Coronary Artery Bypass Grafting.Circulation. Cardiovascular quality and outcomes · 2020
    Article
  10. Article
  11. The Early Diagnostic Value of Procalcitonin in Pneumonia After Off-Pump Coronary Artery Bypass Grafting Surgery.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
  12. Article
  13. Article
  14. Article
  15. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Terry ShihFrom the Departments of Surgery (T.S.), Biostatistics (M.Z.), and Cardiac Surgery (M.K., R.L.P., D.S.L.), University of Michigan, Ann Arbor; Department of Cardiac Surgery, Meijer Heart and Vascular Institute at Spectrum Health, Grand Rapids, MI (T.J.B.); Heart and Vascular Institute, Henry Ford Macomb Hospitals, Clinton Township, MI (S.D.H.); Department of Cardiac Surgery, McLaren Bay Region, Bay City, MI (R.J.H.); Department of Cardiothoracic and Vascular Surgery, McLaren Greater Lansing, MI (G.R.); and Michigan Society of Thoracic and Cardiovascular Surgeons Quality Collaborative, Ann Arbor (P.F.T., R.L.P., D.S.L.).
Min ZhangFrom the Departments of Surgery (T.S.), Biostatistics (M.Z.), and Cardiac Surgery (M.K., R.L.P., D.S.L.), University of Michigan, Ann Arbor; Department of Cardiac Surgery, Meijer Heart and Vascular Institute at Spectrum Health, Grand Rapids, MI (T.J.B.); Heart and Vascular Institute, Henry Ford Macomb Hospitals, Clinton Township, MI (S.D.H.); Department of Cardiac Surgery, McLaren Bay Region, Bay City, MI (R.J.H.); Department of Cardiothoracic and Vascular Surgery, McLaren Greater Lansing, MI (G.R.); and Michigan Society of Thoracic and Cardiovascular Surgeons Quality Collaborative, Ann Arbor (P.F.T., R.L.P., D.S.L.).
Mallika KommareddiFrom the Departments of Surgery (T.S.), Biostatistics (M.Z.), and Cardiac Surgery (M.K., R.L.P., D.S.L.), University of Michigan, Ann Arbor; Department of Cardiac Surgery, Meijer Heart and Vascular Institute at Spectrum Health, Grand Rapids, MI (T.J.B.); Heart and Vascular Institute, Henry Ford Macomb Hospitals, Clinton Township, MI (S.D.H.); Department of Cardiac Surgery, McLaren Bay Region, Bay City, MI (R.J.H.); Department of Cardiothoracic and Vascular Surgery, McLaren Greater Lansing, MI (G.R.); and Michigan Society of Thoracic and Cardiovascular Surgeons Quality Collaborative, Ann Arbor (P.F.T., R.L.P., D.S.L.).
Theodore J BoeveFrom the Departments of Surgery (T.S.), Biostatistics (M.Z.), and Cardiac Surgery (M.K., R.L.P., D.S.L.), University of Michigan, Ann Arbor; Department of Cardiac Surgery, Meijer Heart and Vascular Institute at Spectrum Health, Grand Rapids, MI (T.J.B.); Heart and Vascular Institute, Henry Ford Macomb Hospitals, Clinton Township, MI (S.D.H.); Department of Cardiac Surgery, McLaren Bay Region, Bay City, MI (R.J.H.); Department of Cardiothoracic and Vascular Surgery, McLaren Greater Lansing, MI (G.R.); and Michigan Society of Thoracic and Cardiovascular Surgeons Quality Collaborative, Ann Arbor (P.F.T., R.L.P., D.S.L.).
Steven D HarringtonFrom the Departments of Surgery (T.S.), Biostatistics (M.Z.), and Cardiac Surgery (M.K., R.L.P., D.S.L.), University of Michigan, Ann Arbor; Department of Cardiac Surgery, Meijer Heart and Vascular Institute at Spectrum Health, Grand Rapids, MI (T.J.B.); Heart and Vascular Institute, Henry Ford Macomb Hospitals, Clinton Township, MI (S.D.H.); Department of Cardiac Surgery, McLaren Bay Region, Bay City, MI (R.J.H.); Department of Cardiothoracic and Vascular Surgery, McLaren Greater Lansing, MI (G.R.); and Michigan Society of Thoracic and Cardiovascular Surgeons Quality Collaborative, Ann Arbor (P.F.T., R.L.P., D.S.L.).
Robert J HolmesFrom the Departments of Surgery (T.S.), Biostatistics (M.Z.), and Cardiac Surgery (M.K., R.L.P., D.S.L.), University of Michigan, Ann Arbor; Department of Cardiac Surgery, Meijer Heart and Vascular Institute at Spectrum Health, Grand Rapids, MI (T.J.B.); Heart and Vascular Institute, Henry Ford Macomb Hospitals, Clinton Township, MI (S.D.H.); Department of Cardiac Surgery, McLaren Bay Region, Bay City, MI (R.J.H.); Department of Cardiothoracic and Vascular Surgery, McLaren Greater Lansing, MI (G.R.); and Michigan Society of Thoracic and Cardiovascular Surgeons Quality Collaborative, Ann Arbor (P.F.T., R.L.P., D.S.L.).
Gary RothFrom the Departments of Surgery (T.S.), Biostatistics (M.Z.), and Cardiac Surgery (M.K., R.L.P., D.S.L.), University of Michigan, Ann Arbor; Department of Cardiac Surgery, Meijer Heart and Vascular Institute at Spectrum Health, Grand Rapids, MI (T.J.B.); Heart and Vascular Institute, Henry Ford Macomb Hospitals, Clinton Township, MI (S.D.H.); Department of Cardiac Surgery, McLaren Bay Region, Bay City, MI (R.J.H.); Department of Cardiothoracic and Vascular Surgery, McLaren Greater Lansing, MI (G.R.); and Michigan Society of Thoracic and Cardiovascular Surgeons Quality Collaborative, Ann Arbor (P.F.T., R.L.P., D.S.L.).
Patricia F TheurerFrom the Departments of Surgery (T.S.), Biostatistics (M.Z.), and Cardiac Surgery (M.K., R.L.P., D.S.L.), University of Michigan, Ann Arbor; Department of Cardiac Surgery, Meijer Heart and Vascular Institute at Spectrum Health, Grand Rapids, MI (T.J.B.); Heart and Vascular Institute, Henry Ford Macomb Hospitals, Clinton Township, MI (S.D.H.); Department of Cardiac Surgery, McLaren Bay Region, Bay City, MI (R.J.H.); Department of Cardiothoracic and Vascular Surgery, McLaren Greater Lansing, MI (G.R.); and Michigan Society of Thoracic and Cardiovascular Surgeons Quality Collaborative, Ann Arbor (P.F.T., R.L.P., D.S.L.).
Richard L PragerFrom the Departments of Surgery (T.S.), Biostatistics (M.Z.), and Cardiac Surgery (M.K., R.L.P., D.S.L.), University of Michigan, Ann Arbor; Department of Cardiac Surgery, Meijer Heart and Vascular Institute at Spectrum Health, Grand Rapids, MI (T.J.B.); Heart and Vascular Institute, Henry Ford Macomb Hospitals, Clinton Township, MI (S.D.H.); Department of Cardiac Surgery, McLaren Bay Region, Bay City, MI (R.J.H.); Department of Cardiothoracic and Vascular Surgery, McLaren Greater Lansing, MI (G.R.); and Michigan Society of Thoracic and Cardiovascular Surgeons Quality Collaborative, Ann Arbor (P.F.T., R.L.P., D.S.L.).
Donald S LikoskyFrom the Departments of Surgery (T.S.), Biostatistics (M.Z.), and Cardiac Surgery (M.K., R.L.P., D.S.L.), University of Michigan, Ann Arbor; Department of Cardiac Surgery, Meijer Heart and Vascular Institute at Spectrum Health, Grand Rapids, MI (T.J.B.); Heart and Vascular Institute, Henry Ford Macomb Hospitals, Clinton Township, MI (S.D.H.); Department of Cardiac Surgery, McLaren Bay Region, Bay City, MI (R.J.H.); Department of Cardiothoracic and Vascular Surgery, McLaren Greater Lansing, MI (G.R.); and Michigan Society of Thoracic and Cardiovascular Surgeons Quality Collaborative, Ann Arbor (P.F.T., R.L.P., D.S.L.). likosky@umich.edu.
Michigan Society of Thoracic and Cardiovascular Surgeons Quality Collaborative
Henry Ford Macomb Hospital · USMcLaren Greater Lansing · USSpectrum Health · US

Funding

Vascular Surgery: Research Training in Vascular BiologyT32HL076123 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HENKE, PETER K, WAKEFIELD, THOMAS WILLIAM · 2004 to 2019
$1.9M
Optimizing Prevention of Healthcare-Acquired Infections After Cardiac SurgeryR01HS022535 · AHRQ · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIKOSKY, DONALD S · 2013 to 2016
$1.5M
AHRQ HHS R01 HS022535AHRQ HHS R01HS022535NHLBI NIH HHS 5T32HL07612309NHLBI NIH HHS T32 HL076123
6 · The paper itself

Abstract

backgroundHealth-care-acquired infections (HAIs) are a leading cause of morbidity and mortality after cardiac surgery. Prior work has identified several patient-related risk factors associated with HAIs. We hypothesized that rates of HAIs would differ across institutions, in part attributed to differences in case mix. METHODS AND

resultsWe analyzed 20 896 patients undergoing isolated coronary artery bypass grafting surgery at 33 medical centers in Michigan between January 1, 2009, and June 30, 2012. Overall HAIs included pneumonia, sepsis/septicemia, and surgical site infections, including deep sternal wound, thoracotomy, and harvest/cannulation site infections. We excluded patients presenting with endocarditis. Predicted rates of HAIs were estimated using multivariable logistic regression. Overall rate of HAI was 5.1% (1071 of 20 896; isolated pneumonia, 3.1% [n=644]; isolated sepsis/septicemia, 0.5% [n=99]; isolated deep sternal wound infection, 0.5% [n=96]; isolated harvest/cannulation site, 0.5% [n=97]; isolated thoracotomy, 0.02% [n=5]; multiple infections, 0.6% [n=130]). HAI subtypes differed across strata of center-level HAI rates. Although predicted risk of HAI differed in absolute terms by 2.8% across centers (3.9-6.7%; min:max), observed rates varied by 18.2% (0.9-19.1%).

conclusionsThere was a 18.2% difference in observed HAI rates across medical centers among patients undergoing isolated coronary artery bypass grafting surgery. This variability could not be explained by patient case mix. Future work should focus on the impact of other factors (eg, organizational and systems of clinical care) on risk of HAIs.

Indexed as

AgedAged, 80 and overCoronary Artery BypassFemaleHospitalsHumansIncidenceMaleMichiganMiddle AgedMyocardial IschemiaRetrospective StudiesRisk FactorsSurgical Wound Infectioncardiopulmonary bypassinfectionsurgery

Identifiers

PMID24987052
PMCPMC4130223
OpenAlexW2158459053

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.