ArticleeLife2014
Interactions with RNA direct the Polycomb group protein SCML2 to chromatin where it represses target genes.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 51 citations in OpenAlex.
- Discordant interactions between YAP1 and polycomb group protein SCML2 determine cell fate.iScience · 2023Article
- SCML2 contributes to tumor cell resistance to DNA damage through regulating p53 and CHK1 stability.Cell death and differentiation · 2023Article
- Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- IRF8 is a transcriptional activator of CD37 expression in diffuse large B-cell lymphoma.Blood advances · 2022Article
- Sex Comb on Midleg Like-2 Accelerates Hepatocellular Carcinoma Cell Proliferation and Metastasis by Activating Wnt/β-Catenin/EMT Signaling.Yonsei medical journal · 2021Article
- Malat-1-PRC2-EZH1 interaction supports adaptive oxidative stress dependent epigenome remodeling in skeletal myotubes.Cell death & disease · 2021Article
- Analysis of protein-DNA interactions in chromatin by UV induced cross-linking and mass spectrometry.Nature communications · 2020Article
- Long non-coding RNA-polycomb intimate rendezvous.Open biology · 2020Review
- Toward Development of the Male Pill: A Decade of Potential Non-hormonal Contraceptive Targets.Frontiers in cell and developmental biology · 2020Review
- Multimodal Long Noncoding RNA Interaction Networks: Control Panels for Cell Fate Specification.Genetics · 2019Review
- Gene co-expression network analysis reveals key potential gene modules in utero-vaginal junction associated with duration of fertility trait of breeder hens.Scientific reports · 2019Article
- lncRedibly versatile: biochemical and biological functions of long noncoding RNAs.The Biochemical journal · 2019Review
- A rapidly evolved domain, the SCML2 DNA-binding repeats, contributes to chromatin binding of mouse SCML2†.Biology of reproduction · 2019Article
- TET1 regulates fibroblast growth factor 8 transcription in gonadotropin releasing hormone neurons.PloS one · 2019Article
- Activity-Induced Regulation of Synaptic Strength through the Chromatin Reader L3mbtl1.Cell reports · 2018Article
- High-Quality Genome Assemblies Reveal Long Non-coding RNAs Expressed in Ant Brains.Cell reports · 2018Article
- Sample Preparation for Mass Spectrometry-based Identification of RNA-binding Regions.Journal of visualized experiments : JoVE · 2017Article
- Samd7 is a cell type-specific PRC1 component essential for establishing retinal rod photoreceptor identity.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Sex comb on midleg like-2 is a novel specific marker for the diagnosis of gastroenteropancreatic neuroendocrine tumors.Experimental and therapeutic medicine · 2017Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Polycomb repressive complex-1 (PRC1) is essential for the epigenetic regulation of gene expression. SCML2 is a mammalian homolog of Drosophila SCM, a Polycomb-group protein that associates with PRC1. In this study, we show that SCML2A, an SCML2 isoform tightly associated to chromatin, contributes to PRC1 localization and also directly enforces repression of certain Polycomb target genes. SCML2A binds to PRC1 via its SPM domain and interacts with ncRNAs through a novel RNA-binding region (RBR). Targeting of SCML2A to chromatin involves the coordinated action of the MBT domains, RNA binding, and interaction with PRC1 through the SPM domain. Deletion of the RBR reduces the occupancy of SCML2A at target genes and overexpression of a mutant SCML2A lacking the RBR causes defects in PRC1 recruitment. These observations point to a role for ncRNAs in regulating SCML2 function and suggest that SCML2 participates in the epigenetic control of transcription directly and in cooperation with PRC1.DOI: http://dx.doi.org/10.7554/eLife.02637.001.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.