ReviewEuropean journal of applied physiology2014
Maximal oxygen consumption in healthy humans: theories and facts.
Review in European journal of applied physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Cardiorespiratory and oxygenation responses in iron-deficient anemic women during whole-body exercise under moderate hypoxia.European journal of applied physiology · 2026Trial
- Effectiveness of inspiratory muscle training on sleep and functional capacity to exercise in obstructive sleep apnea: a randomized controlled trial.Sleep & breathing = Schlaf & Atmung · 2018Trial
- Acute effects of high-intensity interval training and moderate-intensity continuous training sessions on cardiorespiratory parameters in healthy young men.European journal of applied physiology · 2017Trial
- Supervised exercise training reduces oxidative stress and cardiometabolic risk in adults with type 2 diabetes: a randomized controlled trial.Scientific reports · 2015Trial
- Cigarette smoking slows the on- and the off- cardiorespiratory and gas-exchange kinetics during moderate exercise in young, physically active adults.European journal of applied physiology · 2026Article
- The Effects of Post-Activation Performance Enhancement on High Intensity Interval Training: A Comparison of Traditional and Cluster Set Protocols.European journal of sport science · 2026Article
- Cardiovascular and peripheral factors affecting the decay of maximal oxygen uptake across the spectrum of age in humans.European journal of applied physiology · 2026Article
- Physiologic and mechanical responses to clustered vs. traditional sprint interval exercise approaches.European journal of applied physiology · 2025Article
- Is maximal oxygen consumption an appropriate metric for metabolic health?European journal of applied physiology · 2025Review
- Energy balance analysis suggests that lactate is not a direct cause of the slow component of oxygen uptake kinetics.European journal of applied physiology · 2025Article
- Lessons from history forFrontiers in physiology · 2025Review
- Effect of a cajuína hydroelectrolytic drink on the physical performance and hydration status of recreational runners.Current research in physiology · 2024Article
- Comparative efficacy of various hypoxic training paradigms on maximal oxygen consumption: A systematic review and network meta-analysis.Journal of exercise science and fitness · 2023Review
- Article
- A century of exercise physiology: key concepts on coupling respiratory oxygen flow to muscle energy demand during exercise.European journal of applied physiology · 2022Review
- What is the physiological impact of reducing the 2,000 m Olympic distance in rowing to 1,500 m and 1,000 m for French young competitive rowers? Insights from the energy system contribution.Frontiers in physiology · 2022Article
- Comment on Poole et al (2022) review on oxygen flux from capillaries to mitochondria.European journal of applied physiology · 2022Article
- Article
- Effect of Six-Minute Walk Test and Incremental Exercise on Inspiratory Capacity, Ventilatory Constraints, Breathlessness and Exercise Performance in Sedentary Male Smokers without Airway Obstruction.International journal of environmental research and public health · 2021Article
- Evaluation of sex-based differences in airway size and the physiological implications.European journal of applied physiology · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article reviews the concept of maximal oxygen consumption ([Formula: see text]) from the perspective of multifactorial models of [Formula: see text] limitation. First, I discuss procedural aspects of [Formula: see text] measurement: the implications of ramp protocols are analysed within the theoretical work of Morton. Then I analyse the descriptive physiology of [Formula: see text], evidencing the path that led to the view of monofactorial cardiovascular or muscular [Formula: see text] limitation. Multifactorial models, generated by the theoretical work of di Prampero and Wagner around the oxygen conductance equation, represented a radical change of perspective. These models are presented in detail and criticized with respect to the ensuing experimental work. A synthesis between them is proposed, demonstrating how much these models coincide and converge on the same conclusions. Finally, I discuss the cases of hypoxia and bed rest, the former as an example of the pervasive effects of the shape of the oxygen equilibrium curve, the latter as a neat example of adaptive changes concerning the entire respiratory system. The conclusion is that the concept of cardiovascular [Formula: see text] limitation is reinforced by multifactorial models, since cardiovascular oxygen transport provides most of the [Formula: see text] limitation, at least in normoxia. However, the same models show that the role of peripheral resistances is significant and cannot be neglected. The role of peripheral factors is greater the smaller is the active muscle mass. In hypoxia, the intervention of lung resistances as limiting factors restricts the role played by cardiovascular and peripheral factors.
Indexed as
Identifiers
24986693What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.