ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2014
A pilot study of the effect of intravenous erythropoetin on improvement of visual function in patients with recent indirect traumatic optic neuropathy.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Traumatic Optic Neuropathy Treatment Trial 2; Efficacy of Different Doses of Erythropoietin. A Multicenter, Double Blind RCT
Effect of Intravenous Methylprednisolone and Intravenous Erythropoietin in Toxic Optic Neuropathies: Randomized Clinical Trial.
Who cites it
17 citing papers in PubMed.
- Combination of intravitreal bevacizumab and erythropoietin versus intravitreal bevacizumab alone for refractory diabetic macular edema: a randomized double-blind clinical trial.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Trial
- Traumatic optic neuropathy treatment trial (TONTT): open label, phase 3, multicenter, semi-experimental trial.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018Trial
- Neuroprotective Effect of Methylene Blue in a Rat Model of Traumatic Optic Neuropathy.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Erythropoietin as a treatment option for indirect traumatic optic neuropathy: A pilot study.Indian journal of ophthalmology · 2023Article
- Commentary: Erythropoietin as a treatment option for indirect optic neuropathy: A pilot study.Indian journal of ophthalmology · 2023Article
- The Association of Erythropoietin and Age-Related Macular Degeneration in Hemodialysis Patients: A Nationwide Population-Based Cohort Study.International journal of molecular sciences · 2022Article
- Erythropoietin in Optic Neuropathies: Current Future Strategies for Optic Nerve Protection and Repair.International journal of molecular sciences · 2022Review
- Traumatic optic neuropathy: a review of current studies.Neurosurgical review · 2022Review
- Erythropoietin Gene Therapy Delays Retinal Degeneration Resulting from Oxidative Stress in the Retinal Pigment Epithelium.Antioxidants (Basel, Switzerland) · 2021Article
- Traumatic Optic Neuropathy.Journal of neurological surgery. Part B, Skull base · 2021Article
- A Systematic Literature Review on Traumatic Optic Neuropathy.Journal of ophthalmology · 2021Review
- Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead.International journal of molecular sciences · 2020Review
- Clinical treatment of traumatic optic neuropathy in children: Summary of 29 cases.Experimental and therapeutic medicine · 2018Article
- Intravitreal erythropoietin injection in late-stage optic neuropathy: a safety study on human.International ophthalmology · 2018Article
- Visual-Evoked-Response-Supported Outcome of Intravitreal Erythropoietin in Management of Indirect Traumatic Optic Neuropathy.Journal of ophthalmology · 2018Article
- Indirect traumatic optic neuropathy.Military Medical Research · 2016Review
- Erythropoietin for Optic Neuritis.Journal of ophthalmic & vision researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo evaluate the efficacy of intravenous erythropoietin (EPO) on improvement of visual function and color vision in patients with recent indirect traumatic optic neuropathy (TON).
methodsIn a case series, 18 eyes of 18 patients with diagnosis of indirect TON with duration of less than 2 weeks underwent 20,000 IU intravenous EPO injections daily for 3 days. Best corrected visual acuity (BCVA) and color vision were checked by Ishihara test before, 1, and 3 months after injections. BCVA and color vision were compared before, 1, and 3 months after injections.
resultsThe mean BCVA improved from a baseline of 2.21 ± 0.97 to 1.48 ± 1.29 and 1.31 ± 1.27 log MAR at months 1 and 3, respectively. The differences were statistically significant (P = 0.001, P < 0.001). Color vision was changed from a baseline 2.24 ± 4.29 to 2.94 ± 4.64 and 3.41 ± 5.09 plates at months 1 and 3, respectively. We observed some qualitative improvement that was, however, statistically insignificant at the time of evaluation. (P = 0.063, P = 0.068).
conclusionThis case series showed noticeable effect of EPO on improvement of visual function in patients with recent indirect TON.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.