ArticleAnnals of biomedical engineering2015
Tortuosity of coronary bifurcation as a potential local risk factor for atherosclerosis: CFD steady state study based on in vivo dynamic CT measurements.
Article in Annals of biomedical engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 78 citations in OpenAlex.
- Trial
- Machine learning-based prediction of hemodynamic parameters in left coronary artery bifurcation: A CFD approach.Heliyon · 2025Article
- Sensitivity of coronary hemodynamics to vascular structure variations in health and disease.Scientific reports · 2025Article
- A new understanding of coronary curvature and haemodynamic impact on the course of plaque onset and progression.Royal Society open science · 2024Article
- Global intracranial arterial tortuosity is associated with intracranial atherosclerotic burden.Scientific reports · 2024Article
- Left main coronary artery morphological phenotypes and its hemodynamic properties.Biomedical engineering online · 2024Article
- Predicting severe proximal left anterior descending coronary artery stenosis using proximal left anterior descending coronary artery tortuosity and the angle between the left main and anterior descending coronary arteries: a retrospective cross-sectional study.Quantitative imaging in medicine and surgery · 2023Article
- Relationship between Coronary Arterial Geometry and the Presence and Extend of Atherosclerotic Plaque Burden: A Review Discussing Methodology and Findings in the Era of Cardiac Computed Tomography Angiography.Diagnostics (Basel, Switzerland) · 2022Review
- Article
- Accuracy of vascular tortuosity measures using computational modelling.Scientific reports · 2022Article
- An Introduction to Biomedical Computational Fluid Dynamics.Advances in experimental medicine and biology · 2021Article
- Assessment of Dynamic Change of Coronary Artery Geometry and Its Relationship to Coronary Artery Disease, Based on Coronary CT Angiography.Journal of digital imaging · 2020Article
- Correlation between geometric parameters of the left coronary artery and hemodynamic descriptors of atherosclerosis: FSI and statistical study.Medical & biological engineering & computing · 2019Article
- Numerical investigation of hemodynamic performance of a stent in the main branch of a coronary artery bifurcation.BioImpacts : BI · 2019Article
- A comprehensive fluid-structure interaction model of the left coronary artery.Journal of biomechanical engineering · 2018Article
- Coronary fractional flow reserve measurements of a stenosed side branch: a computational study investigating the influence of the bifurcation angle.Biomedical engineering online · 2016Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
Abstract
The purpose of the present study was to determine whether in vivo bifurcation geometric factors would permit prediction of the risk of atherosclerosis. It is worldwide accepted that low or oscillatory wall shear stress (WSS) is a robust hemodynamic factor in the development of atherosclerotic plaque and has a strong correlation with the local site of plaque deposition. However, it still remains unclear how coronary bifurcation geometries are correlated with such hemodynamic forces. Computational fluid dynamics simulations were performed on left main (LM) coronary bifurcation geometries derived from CT of eight patients without significant atherosclerosis. WSS amplitudes were accurately quantified at two high risk zones of atherosclerosis, namely at proximal left anterior descending artery (LAD) and at proximal left circumflex artery (LCx), and also at three high WSS concentration sites near the bifurcation. Statistical analysis was used to highlight relationships between WSS amplitudes calculated at these five zones of interest and various geometric factors. The tortuosity index of the LM-LAD segment appears to be an emergent geometric factor in determining the low WSS amplitude at proximal LAD. Strong correlations were found between the high WSS amplitudes calculated at the endothelial regions close to the flow divider. This study not only demonstrated that CT imaging studies of local risk factor for atherosclerosis could be clinically performed, but also showed that tortuosity of LM-LAD coronary branch could be used as a surrogate marker for the onset of atherosclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.