SynthesisPediatric surgery international2014
Prevalence of Hirschsprung's disease in premature infants: a systematic review.
Synthesis in Pediatric surgery international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Updated European Reference Network for rare Inherited and Congenital Digestive and Gastrointestinal Anomalies guidelines for the management of rectosigmoid Hirschsprung's disease 2025.Journal of pediatric gastroenterology and nutrition · 2026Guideline
- The prevalence and clinical presentation of Hirschsprung's disease in preterm infants: a systematic review and meta-analysis.Pediatric surgery international · 2022Pooled it
- When It Is Not NEC: Recognizing Mimics of Necrotizing Enterocolitis in Preterm Infants.Children (Basel, Switzerland) · 2026Review
- An Innovative and Alternative Technique in Total Colonic Hirschsprung Disease (TCHD) Treatment, Two Case Reports.Clinical case reports · 2026Article
- Management of Hirschsprung's Disease: A Survey with Brazilian Pediatric Surgeons.Children (Basel, Switzerland) · 2024Article
- Article
- Hirschsprung disease.Nature reviews. Disease primers · 2023Review
- State of the Art Bowel Management for Pediatric Colorectal Problems: Hirschsprung Disease.Children (Basel, Switzerland) · 2023Review
- [Reporting and mapping of megacolon in a Colombian population: analysis of 10 years and 937 cases].Revista de salud publica (Bogota, Colombia) · 2023Article
- Unbiased characterization of the larval zebrafish enteric nervous system at a single cell transcriptomic level.iScience · 2023Article
- Comparison of Outcomes between Two Surgical Techniques for Patients with Intestinal Neuronal Dysplasia.Journal of immunology research · 2022Article
- Safety and Accuracy of Suction Rectal Biopsy in Preterm Infants.Frontiers in pediatrics · 2021Article
- Postoperative enterocolitis assessment using two different cut-off values in the HAEC score in Hirschsprung patients undergoing Duhamel and Soave pull-through.BMC pediatrics · 2020Article
- ERNICA guidelines for the management of rectosigmoid Hirschsprung's disease.Orphanet journal of rare diseases · 2020Review
- Hirschsprung's disease in the UK and Ireland: incidence and anomalies.Archives of disease in childhood · 2017Article
- Established and emerging concepts in Hirschsprung's-associated enterocolitis.Pediatric surgery international · 2016Review
- A 6-year retrospective review of histopathological pattern of surgical biopsies in children with refractory constipation in a Tertiary Hospital in Ghana.African journal of paediatric surgery : AJPSArticle
- Systematic Review of the Prevalence of Gastrointestinal Congenital Anomalies: A Global and Regional Review Protocol.Sage open pediatricsReview
- The Global Burden of Major Gastrointestinal Anomalies: A Global, Systematic Review of Gastrointestinal Anomaly Birth Prevalence.Sage open pediatricsReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIntestinal dysmotility in preterm infants has often been attributed to immature enteric nervous system. It is frequently reported that Hirschsprung's disease (HD) is rare in premature infants. The exact prevalence of HD in premature infants is not well documented. The classical signs of HD may often not be identified due to the complexity of symptoms of prematurity itself. This systematic review was designed to determine the prevalence and presentation of HD in premature infants.
methodsA systematic review of the literature using the keywords "Hirschsprung's disease", "aganglionosis", "congenital megacolon", "premature" and "preterm" was performed. Resulting publications were reviewed for epidemiology and morbidity. Only infants born <37 weeks of gestation or described as preterm birth by the authors were included. Reference lists were screened for additional relevant studies.
resultsTwenty-six publications from 1964 to 2013 reported data on premature infants with HD. Out of a total number of 4,147 infants, prematurity was recorded in 257 cases, giving a prevalence rate of 6 % of preterm infants diagnosed with HD. During 1964-1999, reported prevalence of HD in premature infants ranged from 1.7 to 9.2 % (overall prevalence 5 %) and during 2000-2013 prevalence ranged from 4 to 19.4 % (overall prevalence 14 %). The prevalence of total colonic aganglionosis in premature infants was 13 % (15 out of 118 infants). Mean gestational age of preterm infants was 34.5 (± 0.7) weeks and mean age at diagnosis ranged from 18.3 days to 3.9 months. Abdominal distension was observed in 80 % of preterm infants, delayed passage of meconium in 57 and 37 % of premature infants presented with bile-stained vomiting.
conclusionIn recent years, higher prevalence of HD has been reported in premature infants compared to previous years. Hirschsprung's disease should be considered in preterm infants presenting with features of intestinal obstruction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.