Evidence map›Paper›PMID 24986024›Full record

ArticlePhotochemistry and photobiology

ROS and p53 in regulation of UVB-induced HDM2 alternative splicing.

Lingying Tong, Shiyong Wu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Photochemistry and photobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. The Photoprotective Effect of S-Methylmethionine Sulfonium in Skin.International journal of molecular sciences · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lingying TongDepartment of Chemistry and Biochemistry, and Molecular and Cellular Biology Program, Edison Biotechnology Institute, Ohio University, Athens, OH.
Shiyong Wu
Ohio University · US

Funding

UV INDUCED AND PERK MEDIATED SIGNALING PATHWAYSR01CA086928 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WU, SHIYONG · 2000 to 2012
$2.1M
NCI NIH HHS R01 CA086928NCI NIH HHS R01 CA86926
6 · The paper itself

Abstract

Alternative splicing plays an important role in proteasome diversity and gene expression regulation in eukaryotic cells. Hdm2, the human homolog of mdm2 (murine double minute oncogene 2), is known to be an oncogene as its role in suppression of p53. Hdm2 alternative splicing, occurs in both tumor and normal tissues, is believed to be a response of cells for cellular stress, and thus modulate p53 activity. Therefore, understanding the regulation of hdm2 splicing is critical in elucidating the mechanisms of tumor development and progression. In this study, we determined the effect of ultraviolet B light (UVB) on alternative splicing of hdm2. Our data indicated that UVB (50 mJ cm(-2)) alone is not a good inducer of alternative splicing of hdm2. The less effectiveness could be due to the induction of ROS and p53 by UVB because removing ROS by L-NAC (10 mm) in p53 null cells could lead to alternative splicing of hdm2 upon UVB irradiation.

Indexed as

Alternative SplicingUltraviolet RaysCell Line, TumorHumansProto-Oncogene Proteins c-mdm2Reactive Oxygen SpeciesTumor Suppressor Protein p53MDM2 protein, humanProto-Oncogene Proteins c-mdm2Reactive Oxygen SpeciesTP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID24986024
PMCPMC4282633
OpenAlexW2050481998

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.