ArticleGenome research2014
Evolution of H3K27me3-marked chromatin is linked to gene expression evolution and to patterns of gene duplication and diversification.
Article in Genome research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 32 citations in OpenAlex.
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- DELLA-mediated gene repression is maintained by chromatin modification in rice.The EMBO journal · 2023Article
- Promoter evolution of mammalian gene duplicates.BMC biology · 2023Article
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- Histone Code and Higher-Order Chromatin Folding: A Hypothesis.Genomics and computational biology · 2017Article
- Parallel evolution of male germline epigenetic poising and somatic development in animals.Nature genetics · 2016Article
- Active and Repressive Chromatin-Associated Proteome after MPA Treatment and the Role of Midkine in Epithelial Monolayer Permeability.International journal of molecular sciences · 2016Article
- Chromatin structure analysis enables detection of DNA insertions into the mammalian nuclear genome.Biochemistry and biophysics reports · 2015Article
- The Role of piRNA-Mediated Epigenetic Silencing in the Population Dynamics of Transposable Elements in Drosophila melanogaster.PLoS genetics · 2015Article
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Histone modifications are critical for the regulation of gene expression, cell type specification, and differentiation. However, evolutionary patterns of key modifications that regulate gene expression in differentiating organisms have not been examined. Here we mapped the genomic locations of the repressive mark histone 3 lysine 27 trimethylation (H3K27me3) in four species of Drosophila, and compared these patterns to those in C. elegans. We found that patterns of H3K27me3 are highly conserved across species, but conservation is substantially weaker among duplicated genes. We further discovered that retropositions are associated with greater evolutionary changes in H3K27me3 and gene expression than tandem duplications, indicating that local chromatin constraints influence duplicated gene evolution. These changes are also associated with concomitant evolution of gene expression. Our findings reveal the strong conservation of genomic architecture governed by an epigenetic mark across distantly related species and the importance of gene duplication in generating novel H3K27me3 profiles.
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