ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2014
APOE ε4 influences β-amyloid deposition in primary progressive aphasia and speech apraxia.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia.Annals of neurology · 2018Pooled it
- Amyloid pet in primary progressive aphasia: case series and systematic review of the literature.Journal of neurology · 2017Pooled it
- Cortical asymmetry in autosomal dominant Alzheimer's disease progression.Brain communications · 2026Article
- Longitudinal characterization of patients with progressive apraxia of speech without clearly predominant phonetic or prosodic speech features.Brain and language · 2023Article
- An Update on Apraxia of Speech.Current neurology and neuroscience reports · 2023Review
- Clinicopathological associations of hemispheric dominance in primary progressive apraxia of speech.European journal of neurology · 2023Article
- Amyloid and Tau PET Positivity in Progressive Agrammatic Aphasia and Apraxia of Speech.Journal of Alzheimer's disease : JAD · 2023Article
- Review
- Alzheimer's disease - the journey of a healthy brain into organ failure.Molecular neurodegeneration · 2022Review
- Missing apolipoprotein E ε4 allele associated with nonamnestic Alzheimer's disease in a Tunisian population.Journal of genetics · 2022Article
- Relationship of APOE, age at onset, amyloid and clinical phenotype in Alzheimer disease.Neurobiology of aging · 2021Article
- Article
- Dementia with Lewy bodies presenting as Logopenic variant primary progressive Aphasia.Neurocase · 2020Article
- Longitudinal flortaucipir ([Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
- Longitudinal Amyloid-β PET in Atypical Alzheimer's Disease and Frontotemporal Lobar Degeneration.Journal of Alzheimer's disease : JAD · 2020Article
- The influence of β-amyloid on [Neurology · 2019Article
- FTD spectrum: Neuroimaging across the FTD spectrum.Progress in molecular biology and translational science · 2019Review
- [Annals of neurology · 2018Article
- Tau-PET imaging with [18F]AV-1451 in primary progressive apraxia of speech.Cortex; a journal devoted to the study of the nervous system and behavior · 2018Article
- Varying Degrees of Temporoparietal Hypometabolism on FDG-PET Reveal Amyloid-Positive Logopenic Primary Progressive Aphasia is not a Homogeneous Clinical Entity.Journal of Alzheimer's disease : JAD · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundApolipoprotein E ε4 (APOE ε4) is a risk factor for β-amyloid deposition in Alzheimer's disease dementia. Its influence on β-amyloid deposition in speech and language disorders, including primary progressive aphasia (PPA), is unclear.
methodsOne hundred thirty subjects with PPA or progressive speech apraxia underwent APOE genotyping and Pittsburgh compound B (PiB) PET scanning. The relationship between APOE ε4 and PiB status, as well as severity and regional distribution of PiB, was assessed.
resultsForty-five subjects had an APOE ε4 allele and 60 subjects were PiB-positive. The odds ratio for a subject with APOE ε4 being PiB-positive compared with a subject without APOE ε4 being PiB-positive was 10.2 (95% confidence interval, 4.4-25.5; P < .0001). The APOE ε4 allele did not influence regional PiB distribution or severity.
conclusionAPOE ε4 increases the risk of β-amyloid deposition in PPA and progressive speech apraxia but does not influence regional β-amyloid distribution or severity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.