Evidence map›Paper›PMID 24985359›Full record

ReviewPatient education and counseling2014

Striking a balance in communicating pharmacogenetic test results: promoting comprehension and minimizing adverse psychological and behavioral response.

Susanne B Haga, Rachel Mills, Hayden Bosworth

Open access · greenAbstract readReview
In one paragraph

Review in Patient education and counseling, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Susanne B HagaInstitute for Genome Sciences & Policy and Sanford School of Public Policy, Duke University, Durham, USA. Electronic address: susanne.haga@duke.edu.
Rachel MillsInstitute for Genome Sciences & Policy, Duke University, Durham, USA.
Hayden BosworthDepartments of Medicine, Psychiatry, and Nursing, Duke University, Center for Health Services Research in Primary Care, Durham VAMC, Durham, USA.
Duke University · US

Funding

Pharmacogenetic Testing: Challenges of Clinical IntegrationR01GM081416 · NIGMS · DUKE UNIVERSITY · PI HAGA, SUSANNE · 2008 to 2018
$4.6M
NIGMS NIH HHS R01 GM081416NIGMS NIH HHS R01GM081416
6 · The paper itself

Abstract

objectivePharmacogenetic (PGx) testing can provide information about a patient's likelihood to respond to a medication or experience an adverse event, and be used to inform medication selection and/or dosing. Promoting patient comprehension of PGx test results will be important to improving engagement and understanding of treatment decisions.

methodsThe discussion in this paper is based on our experiences and the literature on communication of genetic test results for disease risk and broad risk communication strategies.

resultsClinical laboratory reports often describe PGx test results using standard terminology such as 'poor metabolizer' or 'ultra-rapid metabolizer.' While this type of terminology may promote patient recall with its simple, yet descriptive nature, it may be difficult for some patients to comprehend and/or cause adverse psychological or behavioral responses.

conclusionThe language used to communicate results and their significance to patients will be important to consider in order to minimize confusion and potential psychological consequences such as increased anxiety that can adversely impact medication-taking behaviors. PRACTICE IMPLICATIONS: Due to patients' unfamiliarity with PGx testing and the potential for confusion, adverse psychological effects, and decreased medication adherence, health providers need to be cognizant of the language used in discussing PGx test results with patients.

Indexed as

CommunicationComprehensionGenetic CounselingGenetic TestingPharmacogeneticsGenetic Predisposition to DiseaseHumansMedication AdherencePatient Education as TopicCommunication of resultsGenetic testingPatient education

Identifiers

PMID24985359
PMCPMC4162835
OpenAlexW1973181480

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.