ReviewPhysiology (Bethesda, Md.)2014
You're only as old as your arteries: translational strategies for preserving vascular endothelial function with aging.
Review in Physiology (Bethesda, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
98 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of exercise training on arterial stiffness and blood pressure among postmenopausal women: a systematic review and meta-analysis.Systematic reviews · 2024Pooled it
- The role of T-type calcium channels in elderly human vascular function: A pilot randomized controlled trial.Experimental physiology · 2024Trial
- Increased nitrate intake from beetroot juice over 4 weeks affects nitrate metabolism, but not vascular function or blood pressure in older adults with hypertension.Food & function · 2024Trial
- Effect of Intensive Lifestyle Intervention on Cardiovascular Risk Factors: Analysis From the Perspective of Long-Term Variability.Journal of the American Heart Association · 2024Trial
- Trial
- Daily 100% watermelon juice consumption and vascular function among postmenopausal women: A randomized controlled trial.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2021Trial
- Sex differences in endothelial function in chronic kidney disease.American journal of physiology. Renal physiology · 2020Trial
- Trial
- Trial
- Effects of 6-month supplementation with β-hydroxy-β-methylbutyrate, glutamine and arginine on vascular endothelial function of older adults.European journal of clinical nutrition · 2016Trial
- Chronic resistance training does not affect post-exercise blood pressure in normotensive older women: a randomized controlled trial.Age (Dordrecht, Netherlands) · 2015Trial
- Modulating Oxidative Stress and Inflammation in Elders: The MOXIE Study.Journal of nutrition in gerontology and geriatricsTrial
- Cross-Sectional Associations Between Health Behaviors and Intrinsic Capacity Among Older People in Taiwan Across Different Settings: The Role of Regular Physical Activity Engagement.Journal of prevention (2022) · 2026Article
- Cerebrovascular flow-mediated dilation in humans: Methodological challenges, physiological interpretation and future integrations.Experimental physiology · 2026Review
- Influence of exercise training on nitric oxide pathways and their physiological effects.Redox biology · 2026Review
- The Endothelium as a Central Mediator of Exercise-Induced Metabolism and Communication.Exercise and sport sciences reviews · 2026Review
- CardioGAP+: bridging the gap between patient identification and therapy implementation in cardiovascular risk.Frontiers in cardiovascular medicine · 2026Article
- Endothelial dysfunction promotes age-related reorganization of collagen fibers and alters aortic biomechanics in mice.American journal of physiology. Heart and circulatory physiology · 2025Article
- Variability in Arterial Stiffness and Vascular Endothelial Function After COVID-19 During 1.5 Years of Follow-Up-Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2025Review
- Mechanisms of cellular senescence-induced vascular aging: evidence of senotherapeutic strategies.The journal of cardiovascular aging · 2025Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Endothelial dysfunction develops with age and increases the risk of age-associated vascular disorders. Nitric oxide insufficiency, oxidative stress, and chronic low-grade inflammation, induced by upregulation of adverse cellular signaling processes and imbalances in stress resistance pathways, mediate endothelial dysfunction with aging. Healthy lifestyle behaviors preserve endothelial function with aging by inhibiting these mechanisms, and novel nutraceutical compounds that favorably modulate these pathways hold promise as a complementary approach for preserving endothelial health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.