Evidence map›Paper›PMID 24985328›Full record

ReviewPhysiology (Bethesda, Md.)2014

The myoendothelial junction: connections that deliver the message.

Adam C Straub, Angela C Zeigler, Brant E Isakson

Abstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed.

  1. Review
  2. Article
  3. Pericyte Electrical Signalling and Brain Haemodynamics.Basic & clinical pharmacology & toxicology · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Electro-metabolic signaling.The Journal of general physiology · 2024
    Article
  11. Article
  12. Cracking the Endothelial Calcium (CaInternational journal of molecular sciences · 2023
    Review
  13. Article
  14. Review
  15. Vascular mechanotransduction.Physiological reviews · 2023
    Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Elastin, arterial mechanics, and stenosis.American journal of physiology. Cell physiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Adam C StraubVascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania;
Angela C ZeiglerRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia; and.
Brant E IsaksonRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia; and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia brant@virginia.edu.

Funding

BASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6M
Mechanisms of Heterocellular Signaling at the Myoenothelial JunctionR01HL088554 · NHLBI · UNIVERSITY OF VIRGINIA · PI ISAKSON, BRANT E, WEISS, MITCHELL J · 2008 to 2017
$3.8M
Mechanisms of Intracellular NAMPT-regulated GSNOR in Vessel WallR00HL112904 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STRAUB, ADAM CARL · 2013 to 2015
$730k
Mechanism of PAI-1 Polarization to Myoendothelial JunctionsR21HL107963 · NHLBI · UNIVERSITY OF VIRGINIA · PI ISAKSON, BRANT E · 2012 to 2013
$414k
Mechanisms of intracellular NAMPT-regulated GSNOR in vessel wallK99HL112904 · NHLBI · UNIVERSITY OF VIRGINIA · PI STRAUB, ADAM CARL · 2012 to 2012
$90k
NHLBI NIH HHS HL-088554NHLBI NIH HHS HL-107963NHLBI NIH HHS HL-112904NHLBI NIH HHS K99 HL112904NHLBI NIH HHS R00 HL112904NHLBI NIH HHS R01 HL088554NHLBI NIH HHS R21 HL107963NHLBI NIH HHS T32 HL007284
6 · The paper itself

Abstract

A vast amount of investigation has centered on how the endothelium and smooth muscle communicate. From this evidence, myoendothelial junctions have emerged as critical anatomical structures to regulate heterocellular cross talk. Indeed, there is now evidence that the myoendothelial junction serves as a signaling microdomain to organize proteins used to facilitate vascular heterocellular communication. This review highlights the evolving role of myoendothelial junctions in the context of vascular cell-cell communication.

Indexed as

AnimalsBlood PressureCell CommunicationEndothelium, VascularHumansIntercellular JunctionsMuscle, Smooth, VascularSignal TransductionVascular Resistance

Identifiers

PMID24985328
PMCPMC4103062

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.